Saponins from the bark of Nephelium maingayi

Activity-guided fractionation of the bark of Nephelium maingayi, collected in Indonesia, led to the isolation of six new saponins (1-6). The aglycon of 4 was determined to be a new compound, 7alpha-methoxyerythrodiol, and those of 1-3 and of 5 and 6 were identified as erythrodiol and maniladiol (16b...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-02, Vol.67 (2), p.201-205
Main Authors: Ito, A, Chai, H.B, Kardono, L.B.S, Setowati, F.M, Afriastini, J.J, Riswan, S, Farnsworth, N.R, Cordell, G.A, Pezzuto, J.M, Swanson, S.M
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - analysis
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
beta-Glucosidase - metabolism
Biological and medical sciences
Drug Screening Assays, Antitumor
General pharmacology
Humans
Hydrolysis
Indonesia
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Bark - chemistry
Plants, Medicinal - chemistry
Sapindaceae - chemistry
Saponins - analysis
Saponins - chemistry
Saponins - isolation & purification
Saponins - pharmacology
Stereoisomerism
Tumor Cells, Cultured
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Summary:Activity-guided fractionation of the bark of Nephelium maingayi, collected in Indonesia, led to the isolation of six new saponins (1-6). The aglycon of 4 was determined to be a new compound, 7alpha-methoxyerythrodiol, and those of 1-3 and of 5 and 6 were identified as erythrodiol and maniladiol (16beta-hydroxyamyrin), respectively. The structures of 1-6 were determined on the basis of spectral data interpretation, and the absolute configurations of their component monosaccharides were determined as their thiazolidine derivatives after acid hydrolysis. Of the isolates, only compounds 1 and 5 showed very weak cytotoxic activity against a panel of human tumor cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np030389e