Myocardial perfusion in type 2 diabetes with left ventricular hypertrophy: normalisation by acute angiotensin-converting enzyme inhibition

The purpose of this study was to assess whether acute angiotensin-converting enzyme (ACE) inhibition would improve myocardial perfusion and perfusion reserve in a subpopulation of normotensive patients with diabetes and left ventricular hypertrophy (LVH), both independent risk factors of coronary di...

Full description

Saved in:
Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2004-03, Vol.31 (3), p.362-368
Main Authors: Hesse, Birger, Meyer, Christian, Nielsen, Flemming S, Sato, Asako, Hove, Jens D, Holm, Soeren, Bang, Lia E, Kofoed, Klaus F, Svendsen, Tage L, Parving, Hans-Henrik, Opie, Lionel H
Format: Article
Language:English
Subjects:
Ammonia
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Carbon Isotopes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - diagnostic imaging
Diabetes Mellitus, Type 2 - drug therapy
Female
Heart - diagnostic imaging
Heart - drug effects
Humans
Hypertrophy, Left Ventricular - diagnosis
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - drug therapy
Indoles - therapeutic use
Male
Middle Aged
Positron-Emission Tomography - methods
Radiopharmaceuticals
Treatment Outcome
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to assess whether acute angiotensin-converting enzyme (ACE) inhibition would improve myocardial perfusion and perfusion reserve in a subpopulation of normotensive patients with diabetes and left ventricular hypertrophy (LVH), both independent risk factors of coronary disease. Using positron emission tomography (PET), we investigated the response of regional myocardial perfusion to acute ACE inhibition with i.v. infusion of perindoprilat (vs saline infusion as control, minimum interval 3 days) in 12 diabetic patients with LVH. Myocardial perfusion was quantified with PET using nitrogen-13 ammonia infused at rest and during dipyridamole hyperaemia. Twelve healthy control subjects were included in the study, five of whom were also studied with perindoprilat. Mean blood pressure in normo-albuminuric, asymptomatic patients was 123+/-7/65+/-9 mmHg. Compared with controls, maximal perfusion was reduced in patients (1.8+/-0.6 vs 2.5+/-1.0 ml min(-1) g(-1); P
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-003-1388-6