DNA microarrays in the clinic: infectious diseases

We argue that the most-promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries...

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Bibliographic Details
Published in:BioEssays 2008-07, Vol.30 (7), p.673-682
Main Authors: Mikhailovich, Vladimir, Gryadunov, Dmitry, Kolchinsky, Alexander, Makarov, Alexander A, Zasedatelev, Alexander
Format: Article
Language:English
Subjects:
Animals
Bacillus anthracis
Communicable Diseases - diagnosis
Communicable Diseases - economics
Communicable Diseases - genetics
Communicable Diseases - mortality
Drug Resistance, Microbial
Genes, Viral
Human immunodeficiency virus
Humans
Malaria - diagnosis
Malaria - microbiology
Molecular Diagnostic Techniques
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - metabolism
Oligonucleotide Array Sequence Analysis - instrumentation
Oligonucleotide Array Sequence Analysis - methods
Oligonucleotide Array Sequence Analysis - utilization
Public Health - methods
Staphylococcus aureus - genetics
Staphylococcus aureus - metabolism
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Summary:We argue that the most-promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug-resistance patterns, illustrate our main thesis. BioEssays 30:673-682, 2008.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.20781