Copper-Catalyzed Alkyne−Aryne and Alkyne−Alkene−Aryne Coupling Reactions

The efficient copper-catalyzed two-component coupling reaction of alkynes with arynes and the three-component coupling reaction of alkynes with allylic chlorides and arynes have been developed. Copper acetylide was postulated as a transient intermediate for the initiation of the coupling reactions.

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Bibliographic Details
Published in:Organic letters 2008-06, Vol.10 (12), p.2393-2396
Main Authors: Xie, Chunsong, Liu, Leifang, Zhang, Yuhong, Xu, Peixin
Format: Article
Language:English
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Summary:The efficient copper-catalyzed two-component coupling reaction of alkynes with arynes and the three-component coupling reaction of alkynes with allylic chlorides and arynes have been developed. Copper acetylide was postulated as a transient intermediate for the initiation of the coupling reactions.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol800651h