BNP and congestive heart failure

Brain natriuretic peptide (BNP), a peptide hormone secreted chiefly by ventricular myocytes, plays a key role in volume homeostasis. The plasma concentration of BNP is raised in various pathological states, especially heart failure. Many studies suggest that measurement of plasma BNP has clinical ut...

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Bibliographic Details
Published in:Progress in cardiovascular diseases 2002, Vol.44 (4), p.293-321
Main Authors: Cowie, Martin R, Mendez, Gustavo F
Format: Article
Language:English
Subjects:
Biomarkers - blood
Drug Monitoring
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - drug therapy
Humans
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Natriuretic Peptide, Brain - blood
Natriuretic Peptide, Brain - physiology
Nerve Tissue Proteins - blood
Peptide Fragments - blood
Prognosis
Survival Analysis
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - diagnosis
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Summary:Brain natriuretic peptide (BNP), a peptide hormone secreted chiefly by ventricular myocytes, plays a key role in volume homeostasis. The plasma concentration of BNP is raised in various pathological states, especially heart failure. Many studies suggest that measurement of plasma BNP has clinical utility for excluding a diagnosis of heart failure in patients with dyspnea or fluid retention and for providing prognostic information in those with heart failure or other cardiac disease. It may also be of value in identifying patients after myocardial infarction in whom further assessment of cardiac function is likely to be worthwhile. Preliminary evidence suggests that measuring the plasma concentration of BNP may be useful in fine tuning therapy for heart failure. Artificially raising the circulating levels of BNP shows considerable promise as a treatment for heart failure. With simpler assay methods now available, it is likely that many physicians will measure plasma BNP to aid them in the diagnosis, risk stratification, and monitoring of their patients with heart failure or other cardiac dysfunction. Copyright 2002, Elsevier Science (USA). All rights reserved.
ISSN:0033-0620
1532-8643
DOI:10.1053/pcad.2002.24599