Clinical significance of preoperative serum vascular endothelial growth factor levels in patients with colorectal cancer and the effect of tumor surgery

Background. Vascular endothelial growth factor (VEGF) is an angiogenic cytokine involved in the progression of solid tumors. In this study we evaluated the clinical usefulness of preoperative serum VEGF concentrations in patients with colorectal cancer. The changes in serum VEGF levels after tumor s...

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Published in:Surgery 2002-05, Vol.131 (5), p.548-555
Main Authors: Karayiannakis, Anastasios J., Syrigos, Konstantinos N., Zbar, Andrew, Baibas, Nicolaos, Polychronidis, Alexandros, Simopoulos, Constantinos, Karatzas, Gabriel
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Colorectal Neoplasms - blood
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Endothelial Growth Factors - blood
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Lymphokines - blood
Male
Medical sciences
Middle Aged
Prognosis
Stomach, duodenum, intestine, rectum, anus
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Tumors
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
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Summary:Background. Vascular endothelial growth factor (VEGF) is an angiogenic cytokine involved in the progression of solid tumors. In this study we evaluated the clinical usefulness of preoperative serum VEGF concentrations in patients with colorectal cancer. The changes in serum VEGF levels after tumor surgery were also evaluated. Methods. Serum VEGF levels were determined by an enzyme-linked immunosorbent assay in the sera of 61 healthy control subjects and 67 patients with colorectal cancer preoperatively and 7 and 30 days after surgery. Results. Serum VEGF levels in patients with colorectal cancer (median, 492 pg/mL; interquartile range, 281 to 737 pg/mL) were higher (P
ISSN:0039-6060
1532-7361
DOI:10.1067/msy.2002.123011