Heart rate variability in human immunodeficiency virus-positive individuals

Background: Heart rate variability (HRV) is a marker of cardiac autonomic tone. Depressed HRV has been reported in patients with AIDS. We conducted this study to find out if HRV is depressed in human immunodeficiency virus (HIV)-positive individuals without AIDS. Methods: We studied prospectively HR...

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Bibliographic Details
Published in:International journal of cardiology 2004-03, Vol.94 (1), p.1-6
Main Authors: Mittal, Chander Mohan, Wig, Naveet, Mishra, Sundeep, Deepak, K.K.
Format: Article
Language:English
Subjects:
Adult
Arrhythmias
Autonomic function
Autonomic Nervous System Diseases - physiopathology
Biological and medical sciences
Cardiac autonomic tone
Cardiac dysrhythmias
Cardiac function
Cardiology. Vascular system
Down-Regulation
Echocardiography
Electrocardiography
Female
Heart
Heart Rate
HIV Seropositivity - physiopathology
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
RR interval
Vagus
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Background: Heart rate variability (HRV) is a marker of cardiac autonomic tone. Depressed HRV has been reported in patients with AIDS. We conducted this study to find out if HRV is depressed in human immunodeficiency virus (HIV)-positive individuals without AIDS. Methods: We studied prospectively HRV by spectral analysis of short-term electrocardiography (ECG) monitoring in 21 HIV-positives (33±11 years) and in 18 healthy volunteers (31±9 years). None of the HIV-positives had any clinical evidence of autonomic or cardiac dysfunction. Echocardiography was also performed in HIV-seropositives to rule out left ventricular (LV) systolic dysfunction. All these individuals did not have any evidence of AIDS. Results: Mean CD4+ lymphocyte count was 426±166/mm 3. The ejection fraction (EF%) of HIV patients was 62.4±6.4.The total power of HRV was reduced significantly in HIV-positive individuals ( p
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2003.02.002