The Preterm Prediction Study: The value of serum alkaline phosphatase, α-fetoprotein, plasma corticotropin-releasing hormone, and other serum markers for the prediction of spontaneous preterm birth

• Published in: American journal of obstetrics and gynecology 2002-05, Vol.186 (5), p.990-996
• Main Authors: Moawad, Atef H., Goldenberg, Robert L., Mercer, Brian, Meis, Paul J., Iams, Jay D., Das, Anita, Caritis, Steve N., Miodovnik, Menachem, Menard, M.Kathryn, Thurnau, Gary R., Dombrowski, Mitchell, Roberts, James M.
• Format: Article
• Language: English
• Subjects: Alkaline Phosphatase - blood; alpha-Fetoproteins - analysis; Biological and medical sciences; Biomarkers - blood; Case-Control Studies; corticotropin-releasing hormone; Corticotropin-Releasing Hormone - blood; Diseases of mother, fetus and pregnancy; Female; Forecasting; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Infant, Newborn; Infant, Premature; Labor, Obstetric; Medical sciences; Pregnancy; Pregnancy. Fetus. Placenta; Serum alkaline phosphatase; spontaneous preterm birth; α-fetoprotein
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1067/mob.[phone]

Objective: High levels of a number of analytes are found in maternal blood; alkaline phosphatase,α-fetoprotein, and corticotropin-releasing hormone have been associated with spontaneous preterm birth. We investigated the relationship between 8 potential blood markers and subsequent spontaneous preterm birth in asymptomatic pregnant women. Study design: We performed a nested case control study that involved 127 women who were enrolled in the preterm prediction study and who had a singleton spontaneous preterm birth at