Assessment of Portal Venous System Patency in the Liver Transplant Candidate: A Prospective Study Comparing Ultrasound, Microbubble-Enhanced Colour Doppler Ultrasound, with Arteriography and Surgery

AIM: To determine the role of microbubble-enhanced colour Doppler ultrasound (CDUS) in assessing portal venous patency prior to liver transplantation. MATERIALS AND METHODS: Over a 2-year period, all patients with chronic liver disease undergoing routine pre-transplant CDUS examination in whom the p...

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Bibliographic Details
Published in:Clinical radiology 2002-05, Vol.57 (5), p.377-383
Main Authors: Marshall, M.M., Beese, R.C., Muiesan, P., Sarma, D.I., O'Grady, J., Sidhu, P.S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Chronic Disease
Contrast Media
Digestive system. Abdomen
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - surgery
Liver Transplantation
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
Middle Aged
Patient Selection
Portal System - diagnostic imaging
Portal System - surgery
Portography
Predictive Value of Tests
Prospective Studies
Sensitivity and Specificity
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Ultrasonic investigative techniques
Ultrasonography, Doppler, Color - methods
ultrasound (US), contrast studies, portal vein thrombosis, liver transplantation, liver, cirrhosis
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Summary:AIM: To determine the role of microbubble-enhanced colour Doppler ultrasound (CDUS) in assessing portal venous patency prior to liver transplantation. MATERIALS AND METHODS: Over a 2-year period, all patients with chronic liver disease undergoing routine pre-transplant CDUS examination in whom the portal venous system was inadequately demonstrated were recruited to the study. CDUS was performed in 368 patients and 33 patients (9%) were recruited. A repeat CDUS examination following an intravenous bolus injection of the microbubble contrast agent Levovist® (Schering Healthcare AG, Berlin, Germany) was performed. Diagnostic confidence was recorded on a free linear analogue scale for both examinations. Findings were compared with indirect portography and surgery. RESULTS: Of the 33 patients with sub-optimal baseline examinations, improvement in portal vein visualization was achieved in 31 patients (94%). Median diagnostic confidence increased from 50% (interquartile range 30–60) to 90% (interquartile range 75–98) (P
ISSN:0009-9260
1365-229X
DOI:10.1053/crad.2001.0839