Fetal pulmonary artery diameters and their association with lung hypoplasia and postnatal outcome in congenital diaphragmatic hernia

Objective: We hypothesized that fetal branch pulmonary artery (PA) diameters indirectly reflect lung mass and are associated with postnatal outcome in cases of isolated congenital diaphragmatic hernia (CDH). Study Design: We retrospectively reviewed echocardiograms of fetuses with CDH, measuring bra...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2002-05, Vol.186 (5), p.1085-1090
Main Authors: Sokol, Jennifer, Bohn, Desmond, Lacro, Ronald V., Ryan, Greg, Stephens, Derek, Rabinovitch, Marlene, Smallhorn, Jeffrey, Hornberger, Lisa K.
Format: Article
Language:English
Subjects:
Abortion, Induced
Biological and medical sciences
congenital diaphragmatic hernia
Echocardiography
Embryonic and Fetal Development
Fetal echocardiography
Fetus - anatomy & histology
Gynecology. Andrology. Obstetrics
Hernia, Diaphragmatic - physiopathology
Hernias, Diaphragmatic, Congenital
Humans
Infant, Newborn
Lung - abnormalities
Lung - embryology
Lung - pathology
lung hypoplasia
Management. Prenatal diagnosis
Medical sciences
Organ Size
Pregnancy. Fetus. Placenta
Pulmonary Artery - embryology
Pulmonary Artery - pathology
Retrospective Studies
Survival Analysis
Ultrasonography, Prenatal
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Summary:Objective: We hypothesized that fetal branch pulmonary artery (PA) diameters indirectly reflect lung mass and are associated with postnatal outcome in cases of isolated congenital diaphragmatic hernia (CDH). Study Design: We retrospectively reviewed echocardiograms of fetuses with CDH, measuring branch PA diameters and other echocardiographic parameters. Antenatal parameters were correlated with postmortem lung weights in 5 fetuses after pregnancy termination. Fetal echocardiographic measures were correlated with outcome variables in 29 live-born infants with CDH to identify antenatal indices associated with postnatal death and respiratory morbidity. Results: Antenatal branch PA size correlated with postmortem lung weights from 5 terminated fetuses (r = 0.87). In 26 cases of left CDH in which the fetus continued to term, the ipsilateral branch PA diameter was significantly smaller than the contralateral branch PA diameter at presentation (P
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2002.122413