Successful Treatment of a Critically Ill Patient with Disseminated Coccidioidomycosis, Using Adjunctive Interferon-γ

Conventional antifungal therapy was not successful for a critically ill patient who had been hospitalized for 137 days in the intensive care unit with disseminated Coccidioides immitis infection and respiratory failure. The addition of interferon-γ to the therapeutic regimen resulted in improvement...

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Bibliographic Details
Published in:Clinical infectious diseases 2004-03, Vol.38 (6), p.910-912
Main Authors: Kuberski, Timothy T., Servi, Ronald J., Rubin, Phillip J.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - therapeutic use
Antifungals
Biological and medical sciences
Brief Reports
Cell mediated immunity
Coccidioides
Coccidioides immitis
Coccidioidomycosis
Coccidioidomycosis - drug therapy
Critical Care
Critical Illness
Drug Therapy, Combination
Female
Fungal infections
Hospitalization
Human mycoses
Humans
Immune response
Infections
Infectious diseases
Intensive Care Units
Interferon-gamma - therapeutic use
Medical sciences
Middle Aged
Mycoses
Pharmacology. Drug treatments
Tropical mycoses
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Summary:Conventional antifungal therapy was not successful for a critically ill patient who had been hospitalized for 137 days in the intensive care unit with disseminated Coccidioides immitis infection and respiratory failure. The addition of interferon-γ to the therapeutic regimen resulted in improvement and discharge from the hospital. Adjunctive interferon-γ used in the successful treatment of severe coccidioidomycosis has not been reported previously.
ISSN:1058-4838
1537-6591
DOI:10.1086/382075