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Successful Treatment of a Critically Ill Patient with Disseminated Coccidioidomycosis, Using Adjunctive Interferon-γ
Conventional antifungal therapy was not successful for a critically ill patient who had been hospitalized for 137 days in the intensive care unit with disseminated Coccidioides immitis infection and respiratory failure. The addition of interferon-γ to the therapeutic regimen resulted in improvement...
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| Published in: | Clinical infectious diseases 2004-03, Vol.38 (6), p.910-912 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c453t-21b03175a4d119c242d4b83c899f55a906652d2ec31ae55c9d4d3e902b4291023 |
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| cites | cdi_FETCH-LOGICAL-c453t-21b03175a4d119c242d4b83c899f55a906652d2ec31ae55c9d4d3e902b4291023 |
| container_end_page | 912 |
| container_issue | 6 |
| container_start_page | 910 |
| container_title | Clinical infectious diseases |
| container_volume | 38 |
| creator | Kuberski, Timothy T. Servi, Ronald J. Rubin, Phillip J. |
| description | Conventional antifungal therapy was not successful for a critically ill patient who had been hospitalized for 137 days in the intensive care unit with disseminated Coccidioides immitis infection and respiratory failure. The addition of interferon-γ to the therapeutic regimen resulted in improvement and discharge from the hospital. Adjunctive interferon-γ used in the successful treatment of severe coccidioidomycosis has not been reported previously. |
| doi_str_mv | 10.1086/382075 |
| format | article |
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Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Antifungals</subject><subject>Biological and medical sciences</subject><subject>Brief Reports</subject><subject>Cell mediated immunity</subject><subject>Coccidioides</subject><subject>Coccidioides immitis</subject><subject>Coccidioidomycosis</subject><subject>Coccidioidomycosis - drug therapy</subject><subject>Critical Care</subject><subject>Critical Illness</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Hospitalization</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Immune response</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Intensive Care Units</subject><subject>Interferon-gamma - therapeutic use</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycoses</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Antifungals</topic><topic>Biological and medical sciences</topic><topic>Brief Reports</topic><topic>Cell mediated immunity</topic><topic>Coccidioides</topic><topic>Coccidioides immitis</topic><topic>Coccidioidomycosis</topic><topic>Coccidioidomycosis - drug therapy</topic><topic>Critical Care</topic><topic>Critical Illness</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Fungal infections</topic><topic>Hospitalization</topic><topic>Human mycoses</topic><topic>Humans</topic><topic>Immune response</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Intensive Care Units</topic><topic>Interferon-gamma - therapeutic use</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycoses</topic><topic>Pharmacology. Drug treatments</topic><topic>Tropical mycoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuberski, Timothy T.</creatorcontrib><creatorcontrib>Servi, Ronald J.</creatorcontrib><creatorcontrib>Rubin, Phillip J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuberski, Timothy T.</au><au>Servi, Ronald J.</au><au>Rubin, Phillip J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Treatment of a Critically Ill Patient with Disseminated Coccidioidomycosis, Using Adjunctive Interferon-γ</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2004-03-15</date><risdate>2004</risdate><volume>38</volume><issue>6</issue><spage>910</spage><epage>912</epage><pages>910-912</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Conventional antifungal therapy was not successful for a critically ill patient who had been hospitalized for 137 days in the intensive care unit with disseminated Coccidioides immitis infection and respiratory failure. 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| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2004-03, Vol.38 (6), p.910-912 |
| issn | 1058-4838 1537-6591 |
| language | eng |
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| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - therapeutic use Antifungals Biological and medical sciences Brief Reports Cell mediated immunity Coccidioides Coccidioides immitis Coccidioidomycosis Coccidioidomycosis - drug therapy Critical Care Critical Illness Drug Therapy, Combination Female Fungal infections Hospitalization Human mycoses Humans Immune response Infections Infectious diseases Intensive Care Units Interferon-gamma - therapeutic use Medical sciences Middle Aged Mycoses Pharmacology. Drug treatments Tropical mycoses |
| title | Successful Treatment of a Critically Ill Patient with Disseminated Coccidioidomycosis, Using Adjunctive Interferon-γ |
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