Orthopaedic tissue engineering: from laboratory to the clinic

Tissue engineering involves the use of cells (either adult, mesenchymal or embryonic stem cells) coupled with biological or artificial matrices or scaffolds which guide the cells during repair or regeneration of the tissue. Recently discovered and isolated growth factors can promote either adult or...

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Bibliographic Details
Published in:Medical journal of Australia 2004-03, Vol.180 (5), p.S35-S38
Main Author: Oakes, Barry W
Format: Article
Language:English
Subjects:
Adults
Anatomy and physiology
Biological and medical sciences
Bone Regeneration - drug effects
Bone Substitutes - therapeutic use
Cartilage
Cartilage, Articular - injuries
Chondrocytes - transplantation
Collagen
Embryos
Fibrillar Collagens - therapeutic use
Fractures
General aspects
Growth factors
Growth Substances - therapeutic use
Humans
Knee
Knee Injuries - therapy
Ligaments
Ligaments - injuries
Medical sciences
Musculoskeletal diseases
Orthopedics
Orthopedics - methods
Pain
Patients
Stem cells
Tendon Injuries - therapy
Tendons
Tensile strength
Tibial Meniscus Injuries
Tissue engineering
Tissue Engineering - methods
Transplants & implants
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Description
Summary:Tissue engineering involves the use of cells (either adult, mesenchymal or embryonic stem cells) coupled with biological or artificial matrices or scaffolds which guide the cells during repair or regeneration of the tissue. Recently discovered and isolated growth factors can promote either adult or stem‐cell growth and differentiation along selected pathways to re‐form and repair skeletal tissues in adults. Bone repair enhancement and replacement is now possible with the use of tissue‐engineering technologies. It is now possible to repair articular cartilage using the patient's own articular chondrocytes retrieved during arthroscopy, and expanded in vitro. Clinical results of this technique are very satisfactory.
ISSN:0025-729X
1326-5377
DOI:10.5694/j.1326-5377.2004.tb05912.x