Acute renal tubular injury with acute hepatitis A infection: Is it just a coincidence?

Acute renal failure has rarely been reported in association with acute hepatitis A infection. The commonest form of renal injury in such patients has been found to be acute tubular necrosis. We report two cases of hepatitis A infection in which acute renal failure occurred very early in the course o...

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Bibliographic Details
Published in:Nephrology (Carlton, Vic.) Vic.), 2004-02, Vol.9 (1), p.44-46
Main Authors: SHROFF, GAUTAM R, BADVE, SUNIL V, JOSHI, ANAND G, DESAI, DEVENDRA C, ABRAHAM, PHILIP, SIRSAT, RASIKA A
Format: Article
Language:English
Subjects:
acetylcysteine
Acute Disease
Acute Kidney Injury - complications
Adult
Female
fulminant hepatic failure
Hepatitis A - complications
Humans
Male
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Summary:Acute renal failure has rarely been reported in association with acute hepatitis A infection. The commonest form of renal injury in such patients has been found to be acute tubular necrosis. We report two cases of hepatitis A infection in which acute renal failure occurred very early in the course of the illness and had a clinical presentation and recovery pattern suggestive of acute tubular necrosis. In both patients, the clinical course of renal dysfunction was almost parallel to the course of hepatic dysfunction. Patient 1 needed dialysis, whereas patient 2 did not need dialysis and had a very rapid recovery from renal function in spite of having more severe azotaemia. Patient 2 was administered acetylcysteine in high doses for suspected fulminant hepatic failure. A potential benefit of a high dose of acetylcysteine in recovery of renal function from acute tubular necrosis is postulated.
ISSN:1320-5358
1440-1797
DOI:10.1111/j.1440-1797.2003.00224.x