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Site-Specific Modification of Epstein-Barr Virus-Encoded RNA 1 with N²-Benzylguanosine Limits the Binding Sites Occupied by PKR

Examining viral decoys: Epstein–Barr virus (EBV) generates small RNA inhibitors of the human RNA‐dependent protein kinase (PKR). We demonstrate that chemical synthesis of analogues of the EBV PKR inhibitor EBER1 bearing single N2‐benzylguanosine substitutions (BnG6 or BnG29) can be used to control t...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2004-03, Vol.5 (3), p.383-386
Main Authors: Puthenveetil, Sujiet, Véliz, Eduardo A, Beal, Peter A
Format: Article
Language:English
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Summary:Examining viral decoys: Epstein–Barr virus (EBV) generates small RNA inhibitors of the human RNA‐dependent protein kinase (PKR). We demonstrate that chemical synthesis of analogues of the EBV PKR inhibitor EBER1 bearing single N2‐benzylguanosine substitutions (BnG6 or BnG29) can be used to control the way PKR binds this RNA.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200300816