Microprocessor-controlled colonic peristalsis: Dynamic parametric modeling in dogs

The study aimed at completing a model of functional colonic electric stimulation and testing it for artificial recreation of peristalsis in dogs. Dynamic measurements of invoked single contractions obtained from two unconscious dogs as well as previously reported static contraction properties were u...

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Bibliographic Details
Published in:Digestive diseases and sciences 2002-05, Vol.47 (5), p.1034-1048
Main Authors: RASHEV, Peter Z, AMARIS, Manuel, BOWES, Kenneth L, MINTCHEV, Martin P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Colon - physiology
Digestive system
Dogs
Electric Stimulation
Electrodes
Female
Gastrointestinal Contents
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Microcomputers
Models, Biological
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Peristalsis - physiology
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Summary:The study aimed at completing a model of functional colonic electric stimulation and testing it for artificial recreation of peristalsis in dogs. Dynamic measurements of invoked single contractions obtained from two unconscious dogs as well as previously reported static contraction properties were utilized to suggest the optimal stimulation parameters of: (1) length of the stimulating electrodes, (2) separation between the successive electrode sets, (3) duration, and (4) phase lag between the stimuli sequentially applied to the electrode sets. The derived electrode configuration and stimulation pattern were adjusted for different anatomical dimensions and tested in distended colon full of viscous content. Forward and backward propagating peristaltic waves were invoked in two other unconscious dogs, indicating that the recreation of colonic peristalsis under microprocessor control is feasible.
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1015033906406