Urinary N-acetyl-β-D-glucosaminidase activity in healthy children

Aim:  The principal aim was to establish paediatric reference data for the urinary N‐acetyl‐β‐D‐glucosaminidase  (U‐NAG)  activity. Method and Results:  Two  hundred  and  sixty‐two  healthy  children  aged  0–18 years (0–1 month, n = 38; 1 month−1 year, n = 50; 1–3 years, n = 50; 3–6 years, n = 46;...

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Bibliographic Details
Published in:Nephrology (Carlton, Vic.) Vic.), 2004-02, Vol.9 (1), p.19-21
Main Authors: Skalova, Sylvia, Chladek, Jaroslav
Format: Article
Language:English
Subjects:
Acetylglucosaminidase - urine
Adolescent
Child
Child, Preschool
children
Female
Humans
Infant
Infant, Newborn
Male
Reference Values
urinary N-acetyl-β-D-glucosaminidase
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Summary:Aim:  The principal aim was to establish paediatric reference data for the urinary N‐acetyl‐β‐D‐glucosaminidase  (U‐NAG)  activity. Method and Results:  Two  hundred  and  sixty‐two  healthy  children  aged  0–18 years (0–1 month, n = 38; 1 month−1 year, n = 50; 1–3 years, n = 50; 3–6 years, n = 46; 6–10 years, n = 29; 10–18 years, n = 49) had a urine sample collected and the U‐NAG activity was evaluated by using fluorimetry and related to urinary creatinine as a nkat/mmol ratio. A strong age dependence of the U‐NAG/creatinine ratio and its high interindividual variability in children was observed; the highest values of upper reference range being in the 0–1 month and 1 month−1 year groups (134.8 and 50, respectively), which dropped gradually to 7.25 in the oldest age group (10–18 years). Conclusion:  The establishment of urinary NAG reference paediatric values is a potentially useful tool for the proper evaluation of renal tubular impairment in children.
ISSN:1320-5358
1440-1797
DOI:10.1111/j.1440-1797.2003.00217.x