Probing Protein-Carbohydrate Interactions with Microarrays of Synthetic Oligosaccharides

On the spot: Carbohydrate microarrays, in concert with surface plasmon resonance, are valuable tools in the rapid identification of carbohydrate–protein interactions, like those between high‐mannose oligosaccharides and cyanovirin‐N (see picture). By utilizing chemical methods amenable to current hi...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2004-03, Vol.5 (3), p.379-383
Main Authors: Ratner, Daniel M, Adams, Eddie W, Su, Jing, O'Keefe, Barry R, Mrksich, Milan, Seeberger, Peter H
Format: Article
Language:English
Subjects:
carbohydrate chips
Carbohydrate Metabolism
carbohydrates
lectins
Ligands
microarrays
Microchemistry
Oligosaccharides - chemical synthesis
Protein Array Analysis - methods
Protein Binding
proteins
Proteins - metabolism
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Summary:On the spot: Carbohydrate microarrays, in concert with surface plasmon resonance, are valuable tools in the rapid identification of carbohydrate–protein interactions, like those between high‐mannose oligosaccharides and cyanovirin‐N (see picture). By utilizing chemical methods amenable to current high‐throughput screening technologies, high‐density carbohydrate microarrays can be prepared and screened by using conventional and widely accessible DNA microarray screening instrumentation.
ISSN:1439-4227
1439-7633
1439-4227
DOI:10.1002/cbic.200300804