Electrochemical sensing of DNA–adriamycin interactions

Adriamycin, a cancerostatic anthracycline antibiotic, causes considerable death of tumour cells, together with the induction of breaks in DNA single and double strands. The interaction of this compound with DNA was investigated using an electrochemical DNA-biosensor. Adriamycin intercalation in DNA...

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Bibliographic Details
Published in:Bioelectrochemistry (Amsterdam, Netherlands) Netherlands), 2002-05, Vol.56 (1), p.81-83
Main Authors: Piedade, J.A.P., Fernandes, I.R., Oliveira-Brett, A.M.
Format: Article
Language:English
Subjects:
8-oxoguanine
Adriamycin
Animals
Biosensing Techniques
Cattle
DNA - chemistry
DNA-biosensor
Doxorubicin - chemistry
Electrochemistry - methods
Oxidative damage
Voltammetry
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Summary:Adriamycin, a cancerostatic anthracycline antibiotic, causes considerable death of tumour cells, together with the induction of breaks in DNA single and double strands. The interaction of this compound with DNA was investigated using an electrochemical DNA-biosensor. Adriamycin intercalation in DNA disrupts the double helix and the detection of guanine and 8-oxoguanine could mimic one possible mechanism for the in vivo adriamycin drug action.
ISSN:1567-5394
DOI:10.1016/S1567-5394(02)00013-0