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Increased circulating and intrahepatic T‐cell‐specific chemokines in chronic hepatitis C: relationship with the type of virological response to peginterferon plus ribavirin combination therapy
Summary Aims : To determine the serum and intrahepatic levels of T‐helper‐1‐associated chemokines in patients with chronic hepatitis C before, during and after peginterferon plus ribavirin combination therapy and to search for correlations with baseline characteristics of hepatitis C virus‐related c...
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| Published in: | Alimentary pharmacology & therapeutics 2004-03, Vol.19 (5), p.551-562 |
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| cited_by | cdi_FETCH-LOGICAL-c4452-c1332beb2eef066de42c978f5524aca5109220ccea25c2fed52c324e161a20543 |
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| cites | cdi_FETCH-LOGICAL-c4452-c1332beb2eef066de42c978f5524aca5109220ccea25c2fed52c324e161a20543 |
| container_end_page | 562 |
| container_issue | 5 |
| container_start_page | 551 |
| container_title | Alimentary pharmacology & therapeutics |
| container_volume | 19 |
| creator | Apolinario, A. Diago, M. Lo Iacono, O. Lorente, R. Pérez, C. Majano, P. L. Clemente, G. García‐Monzón, C. |
| description | Summary
Aims : To determine the serum and intrahepatic levels of T‐helper‐1‐associated chemokines in patients with chronic hepatitis C before, during and after peginterferon plus ribavirin combination therapy and to search for correlations with baseline characteristics of hepatitis C virus‐related chronic liver disease and type of therapeutic response.
Methods : Serum chemokine levels were determined by enzyme‐linked immunosorbent assays and intrahepatic chemokine messenger RNA and protein levels were tested by ribonuclease protection assay and immunohistochemistry.
Results : Serum and intrahepatic chemokine levels were elevated in all patients with chronic hepatitis C and showed a marked decrease in patients who obtained a virological response vs. non‐responders. Increased serum interferon‐γ‐inducible protein‐10 levels at baseline in genotype 1‐infected patients were significantly associated with greater degrees of intrahepatic inflammation and fibrosis (P = 0.0046 and P = 0.02, respectively) and with virological non‐response (P = 0.01). In patients with genotype 1, basal serum interferon‐γ‐inducible protein‐10 levels greater than 299 pg/mL identified 80% of non‐responders and lower than 299 pg/mL identified 63% of responders.
Conclusions : Circulating and intrahepatic T‐helper‐1‐associated chemokines are abnormally elevated in patients with chronic hepatitis C. Increased baseline serum interferon‐γ‐inducible protein‐10 levels in genotype 1‐infected patients are associated with virological non‐response to peginterferon plus ribavirin combination therapy. |
| doi_str_mv | 10.1111/j.1365-2036.2004.01872.x |
| format | article |
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Aims : To determine the serum and intrahepatic levels of T‐helper‐1‐associated chemokines in patients with chronic hepatitis C before, during and after peginterferon plus ribavirin combination therapy and to search for correlations with baseline characteristics of hepatitis C virus‐related chronic liver disease and type of therapeutic response.
Methods : Serum chemokine levels were determined by enzyme‐linked immunosorbent assays and intrahepatic chemokine messenger RNA and protein levels were tested by ribonuclease protection assay and immunohistochemistry.
Results : Serum and intrahepatic chemokine levels were elevated in all patients with chronic hepatitis C and showed a marked decrease in patients who obtained a virological response vs. non‐responders. Increased serum interferon‐γ‐inducible protein‐10 levels at baseline in genotype 1‐infected patients were significantly associated with greater degrees of intrahepatic inflammation and fibrosis (P = 0.0046 and P = 0.02, respectively) and with virological non‐response (P = 0.01). In patients with genotype 1, basal serum interferon‐γ‐inducible protein‐10 levels greater than 299 pg/mL identified 80% of non‐responders and lower than 299 pg/mL identified 63% of responders.
Conclusions : Circulating and intrahepatic T‐helper‐1‐associated chemokines are abnormally elevated in patients with chronic hepatitis C. Increased baseline serum interferon‐γ‐inducible protein‐10 levels in genotype 1‐infected patients are associated with virological non‐response to peginterferon plus ribavirin combination therapy.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2004.01872.x</identifier><identifier>PMID: 14987324</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Antiviral Agents - therapeutic use ; Biological and medical sciences ; Cytokines - metabolism ; Digestive system ; Drug Therapy, Combination ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - metabolism ; Humans ; Immunohistochemistry ; Interferon alpha-2 ; Interferon-alpha ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Polyethylene Glycols ; Recombinant Proteins ; Ribavirin - therapeutic use ; T-Lymphocytes - metabolism ; Viral Load</subject><ispartof>Alimentary pharmacology & therapeutics, 2004-03, Vol.19 (5), p.551-562</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4452-c1332beb2eef066de42c978f5524aca5109220ccea25c2fed52c324e161a20543</citedby><cites>FETCH-LOGICAL-c4452-c1332beb2eef066de42c978f5524aca5109220ccea25c2fed52c324e161a20543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15573274$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14987324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Apolinario, A.</creatorcontrib><creatorcontrib>Diago, M.</creatorcontrib><creatorcontrib>Lo Iacono, O.</creatorcontrib><creatorcontrib>Lorente, R.</creatorcontrib><creatorcontrib>Pérez, C.</creatorcontrib><creatorcontrib>Majano, P. L.</creatorcontrib><creatorcontrib>Clemente, G.</creatorcontrib><creatorcontrib>García‐Monzón, C.</creatorcontrib><title>Increased circulating and intrahepatic T‐cell‐specific chemokines in chronic hepatitis C: relationship with the type of virological response to peginterferon plus ribavirin combination therapy</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Aims : To determine the serum and intrahepatic levels of T‐helper‐1‐associated chemokines in patients with chronic hepatitis C before, during and after peginterferon plus ribavirin combination therapy and to search for correlations with baseline characteristics of hepatitis C virus‐related chronic liver disease and type of therapeutic response.
Methods : Serum chemokine levels were determined by enzyme‐linked immunosorbent assays and intrahepatic chemokine messenger RNA and protein levels were tested by ribonuclease protection assay and immunohistochemistry.
Results : Serum and intrahepatic chemokine levels were elevated in all patients with chronic hepatitis C and showed a marked decrease in patients who obtained a virological response vs. non‐responders. Increased serum interferon‐γ‐inducible protein‐10 levels at baseline in genotype 1‐infected patients were significantly associated with greater degrees of intrahepatic inflammation and fibrosis (P = 0.0046 and P = 0.02, respectively) and with virological non‐response (P = 0.01). In patients with genotype 1, basal serum interferon‐γ‐inducible protein‐10 levels greater than 299 pg/mL identified 80% of non‐responders and lower than 299 pg/mL identified 63% of responders.
Conclusions : Circulating and intrahepatic T‐helper‐1‐associated chemokines are abnormally elevated in patients with chronic hepatitis C. Increased baseline serum interferon‐γ‐inducible protein‐10 levels in genotype 1‐infected patients are associated with virological non‐response to peginterferon plus ribavirin combination therapy.</description><subject>Adult</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cytokines - metabolism</subject><subject>Digestive system</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Hepatitis C, Chronic - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Interferon alpha-2</subject><subject>Interferon-alpha</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyethylene Glycols</subject><subject>Recombinant Proteins</subject><subject>Ribavirin - therapeutic use</subject><subject>T-Lymphocytes - metabolism</subject><subject>Viral Load</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkc9u1DAQxi0EosvCKyBf4JZgO3GSReJQrfhTqRIclrPlOJONl8Q2dkK7Nx6hD9Un4Umwuyt6xZI19vg331jzIYQpyWlc7w45LSqeMVJUOSOkzAltapbfPkGrfw9P0YqwapOxhhYX6EUIB0JIVRP2HF3QctPUBStX6P7KKA8yQIeV9moZ5azNHkvTYW1mLwdwMaPw7s_vOwXjGENwoHQfc2qAyf7QBkJk481bE7OnilkHvH2PPSRBa8KgHb7R84DnAfB8dIBtj39pb0e710qOkQwucvHRYgf72Bx8D1ESu3EJ2OtWRjz1sVOrzYNqEvPSHV-iZ70cA7w6xzX6_unjbvslu_76-Wp7eZ2psuQsU7QoWAstA-hJVXVQMrWpm55zVkolOSUbxohSIBlXrIeOMxWHBLSikhFeFmv09qTrvP25QJjFpEOaijRglyBqWpOCxL1GzQlU3obgoRfO60n6o6BEJAfFQSSjRDJKJAfFg4PiNpa-PvdY2gm6x8KzZRF4cwZkiIPrvTRKh0eO84jViftw4m70CMf__oC4_LZLp-Iv8bm-2Q</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>Apolinario, A.</creator><creator>Diago, M.</creator><creator>Lo Iacono, O.</creator><creator>Lorente, R.</creator><creator>Pérez, C.</creator><creator>Majano, P. L.</creator><creator>Clemente, G.</creator><creator>García‐Monzón, C.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200403</creationdate><title>Increased circulating and intrahepatic T‐cell‐specific chemokines in chronic hepatitis C: relationship with the type of virological response to peginterferon plus ribavirin combination therapy</title><author>Apolinario, A. ; Diago, M. ; Lo Iacono, O. ; Lorente, R. ; Pérez, C. ; Majano, P. L. ; Clemente, G. ; García‐Monzón, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4452-c1332beb2eef066de42c978f5524aca5109220ccea25c2fed52c324e161a20543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cytokines - metabolism</topic><topic>Digestive system</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatitis C, Chronic - drug therapy</topic><topic>Hepatitis C, Chronic - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Interferon alpha-2</topic><topic>Interferon-alpha</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyethylene Glycols</topic><topic>Recombinant Proteins</topic><topic>Ribavirin - therapeutic use</topic><topic>T-Lymphocytes - metabolism</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Apolinario, A.</creatorcontrib><creatorcontrib>Diago, M.</creatorcontrib><creatorcontrib>Lo Iacono, O.</creatorcontrib><creatorcontrib>Lorente, R.</creatorcontrib><creatorcontrib>Pérez, C.</creatorcontrib><creatorcontrib>Majano, P. L.</creatorcontrib><creatorcontrib>Clemente, G.</creatorcontrib><creatorcontrib>García‐Monzón, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Apolinario, A.</au><au>Diago, M.</au><au>Lo Iacono, O.</au><au>Lorente, R.</au><au>Pérez, C.</au><au>Majano, P. L.</au><au>Clemente, G.</au><au>García‐Monzón, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased circulating and intrahepatic T‐cell‐specific chemokines in chronic hepatitis C: relationship with the type of virological response to peginterferon plus ribavirin combination therapy</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2004-03</date><risdate>2004</risdate><volume>19</volume><issue>5</issue><spage>551</spage><epage>562</epage><pages>551-562</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Aims : To determine the serum and intrahepatic levels of T‐helper‐1‐associated chemokines in patients with chronic hepatitis C before, during and after peginterferon plus ribavirin combination therapy and to search for correlations with baseline characteristics of hepatitis C virus‐related chronic liver disease and type of therapeutic response.
Methods : Serum chemokine levels were determined by enzyme‐linked immunosorbent assays and intrahepatic chemokine messenger RNA and protein levels were tested by ribonuclease protection assay and immunohistochemistry.
Results : Serum and intrahepatic chemokine levels were elevated in all patients with chronic hepatitis C and showed a marked decrease in patients who obtained a virological response vs. non‐responders. Increased serum interferon‐γ‐inducible protein‐10 levels at baseline in genotype 1‐infected patients were significantly associated with greater degrees of intrahepatic inflammation and fibrosis (P = 0.0046 and P = 0.02, respectively) and with virological non‐response (P = 0.01). In patients with genotype 1, basal serum interferon‐γ‐inducible protein‐10 levels greater than 299 pg/mL identified 80% of non‐responders and lower than 299 pg/mL identified 63% of responders.
Conclusions : Circulating and intrahepatic T‐helper‐1‐associated chemokines are abnormally elevated in patients with chronic hepatitis C. Increased baseline serum interferon‐γ‐inducible protein‐10 levels in genotype 1‐infected patients are associated with virological non‐response to peginterferon plus ribavirin combination therapy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>14987324</pmid><doi>10.1111/j.1365-2036.2004.01872.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antiviral Agents - therapeutic use Biological and medical sciences Cytokines - metabolism Digestive system Drug Therapy, Combination Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - metabolism Humans Immunohistochemistry Interferon alpha-2 Interferon-alpha Male Medical sciences Pharmacology. Drug treatments Polyethylene Glycols Recombinant Proteins Ribavirin - therapeutic use T-Lymphocytes - metabolism Viral Load |
| title | Increased circulating and intrahepatic T‐cell‐specific chemokines in chronic hepatitis C: relationship with the type of virological response to peginterferon plus ribavirin combination therapy |
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