Heterotopic graft of infant rat brain as an ischemic model for prolonged whole-brain ischemia

By using a heterotopic brain graft model, we have made histological and electrophysiological studies of the infant rat brain after prolonged ischemia. An infant rat head which had undergone ischemia for more than 90 min, was grafted onto an adult rat by anastomosing the thoracic vessels to the femor...

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Bibliographic Details
Published in:Neuroscience letters 2002-05, Vol.325 (1), p.37-41
Main Authors: Niu, Atsushi, Shimazaki, Kuniko, Sugawara, Yasushi, Mizui, Toshiyuki, Kawai, Nobufumi
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Brain - growth & development
Brain - pathology
Brain - physiopathology
Brain graft
Brain Ischemia - pathology
Brain Ischemia - physiopathology
CA1
Cell Division
Cell Movement
Cerebellum
Cerebellum - pathology
Cerebellum - physiopathology
Chronic Disease
Development
Disease Models, Animal
Hippocampus
Infant
Interneurons - pathology
Interneurons - physiology
Ischemia
Long-Term Potentiation
Male
Medical sciences
Nerve Tissue - transplantation
Neurology
Rat
Rats
Rats, Inbred Lew
Reference Values
Synaptic Transmission
Transplantation, Heterotopic
Vascular diseases and vascular malformations of the nervous system
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Summary:By using a heterotopic brain graft model, we have made histological and electrophysiological studies of the infant rat brain after prolonged ischemia. An infant rat head which had undergone ischemia for more than 90 min, was grafted onto an adult rat by anastomosing the thoracic vessels to the femoral vessels of the host rat. Histological and histochemical studies carried out 10 days after the operation showed that the development of the hippocampus and cerebellum in the grafted brain appeared to be normal. Interneuron growth in the hippocampus and migration of the granule cells in the cerebellum had occurred to a similar extent as in control rats. Extracellular recordings in the hippocampus showed normal characteristics of the postsynaptic potentials including long-term potentiation. This heterotopic graft model would be useful for studying brain function after long periods of ischemia.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)00213-6