Study of the Chemical and Physical Influences upon in Vitro Peptide-Mediated Silica Formation

Herein, we report on the ability to create complex 2-D and 3-D silica networks in vitro via polycationic peptide-mediated biosilicification under experimentally altered chemical and physical influences. These structures differ from the sphere-like silica network of particles obtained in vitro under...

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Bibliographic Details
Published in:Biomacromolecules 2004-03, Vol.5 (2), p.261-265
Main Authors: Rodríguez, Francisco, Glawe, Diana D, Naik, Rajesh R, Hallinan, Kevin P, Stone, Morley O
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Biological and medical sciences
Chemistry
Cross-disciplinary physics: materials science
rheology
Elements and non-metal compounds (oxides, hydroxides, hydrides, sulfides, carbides, ...)
Exact sciences and technology
Inorganic chemistry and origins of life
Materials science
Medical sciences
Methods of nanofabrication
Microscopy, Electron, Scanning
Molecular Sequence Data
Peptides - chemistry
Physics
Polyamines - chemistry
Preparations and properties
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Silicon Dioxide - chemistry
Static Electricity
Supramolecular and biochemical assembly
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:Herein, we report on the ability to create complex 2-D and 3-D silica networks in vitro via polycationic peptide-mediated biosilicification under experimentally altered chemical and physical influences. These structures differ from the sphere-like silica network of particles obtained in vitro under static conditions. Under chemical influences, overall morphologies were observed to shift from a characteristic network of sphere-like silica particles to a sheetlike structure in the presence of −OH groups from additives and to sharp-edged, platelike structures in the presence of larger polycationic peptide matrixes. Under physical influences, using externally applied force fields, overall silica morphologies were observed to transition from sphere-like to fiberlike and dendrite-like structures. These findings could lead to the future development of bio-inspired complex 2-D and 3-D silica micro- and nano-devices.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm034232c