Somatotroph and Corticotroph Pituitary Adenoma (Double Adenoma) in a Cat with Diabetes Mellitus and Hyperadrenocorticism

A 9-year-old castrated male European shorthair cat with insulin-resistant diabetes was referred with the preliminary diagnosis of pituitary-dependent hyperadrenocorticism, based on measurements of urinary corticoids. Further studies revealed not only resistance of plasma concentrations of cortisol,...

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Bibliographic Details
Published in:Journal of comparative pathology 2004-02, Vol.130 (2), p.209-215
Main Authors: Meij, B.P., van der Vlugt-Meijer, R.H., van den Ingh, T.S.G.A.M., Rijnberk, A.
Format: Article
Language:English
Subjects:
acromegaly
Adenoma - complications
Adenoma - pathology
Adenoma - veterinary
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - metabolism
alpha-MSH - blood
Animals
cat
Cat Diseases - pathology
Cat Diseases - physiopathology
Cats
Cushing Syndrome - etiology
Cushing Syndrome - veterinary
Cushing's disease
Diabetes Mellitus - etiology
Diabetes Mellitus - veterinary
double adenoma
Growth Hormone - blood
Growth Hormone - metabolism
Hydrocortisone - blood
hypophysectomy
Insulin Resistance
Insulin-Like Growth Factor I - analysis
Male
man
pituitary
Pituitary Neoplasms - complications
Pituitary Neoplasms - pathology
Pituitary Neoplasms - veterinary
tumour
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Summary:A 9-year-old castrated male European shorthair cat with insulin-resistant diabetes was referred with the preliminary diagnosis of pituitary-dependent hyperadrenocorticism, based on measurements of urinary corticoids. Further studies revealed not only resistance of plasma concentrations of cortisol, adrenocorticotropic hormone (ACTH) and α-melanocyte-stimulating hormone (α-MSH) to suppression by a low dose of dexamethasone, but also elevated plasma concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-I). Pituitary imaging with dynamic contrast-enhanced computed tomography demonstrated an enlarged pituitary gland and an adenoma. The cat underwent trans-sphenoidal hypophysectomy after which the insulin resistance disappeared. On histopathological and immunocytochemical examination of the surgical specimen a double adenoma was found, consisting of a corticotroph adenoma and a somatotroph adenoma separated by unaffected pituitary tissue.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2003.09.004