Chromosome 19q13 and multiple sclerosis susceptibility in Finland: a linkage and two-stage association study

Several studies have previously provided some albeit weak evidence for linkage or association between chromosome 19q13 and multiple sclerosis (MS) susceptibility. We performed a two-stage association analysis with 19 markers spanning 7 Mb/5.5 cM of 19q13. In stage 1 analysis (135 MS families) alleli...

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Bibliographic Details
Published in:Journal of neuroimmunology 2002-05, Vol.126 (1), p.134-142
Main Authors: Reunanen, K, Finnilä, S, Laaksonen, M, Sumelahti, M.-L, Wikström, J, Pastinen, T, Kuokkanen, S, Saarela, J, Uimari, P, Ruutiainen, J, Ilonen, J, Peltonen, L, Tienari, P.J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
ApoE
Chromosome 19
Chromosomes, Human, Pair 19
Family Health
Female
Finland
Genetic Linkage
Genetic Predisposition to Disease
Genetics
HLA-DR Antigens - genetics
HLA-DR Serological Subtypes
Humans
Male
Microsatellite Repeats
Middle Aged
Multiple sclerosis
Multiple Sclerosis - genetics
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Summary:Several studies have previously provided some albeit weak evidence for linkage or association between chromosome 19q13 and multiple sclerosis (MS) susceptibility. We performed a two-stage association analysis with 19 markers spanning 7 Mb/5.5 cM of 19q13. In stage 1 analysis (135 MS families) allelic and haplotypic associations were found with markers within or close to the ApoE–ApoC subregion. These observations were taken as a hypothesis, which was tested in stage 2 in 125 families. However, none of the initial associations were replicated suggesting that they were most likely due to chance. Linkage analysis was performed in 27 Finnish multiplex families using 10 microsatellites spanning 23 Mb/24 cM of 19q13. DNA was available from 72 MS patients and 150 unaffected relatives. Parametric and non-parametric linkage analyses did not provide evidence for linkage when all families were tested. After stratifying the families according to HLA-DR15 there was weak evidence for linkage to the 19q13.1 subregion in DR15 negative families (LOD max=1.8). Taken together these results do not support a major role of chromosome 19q13.2–q13.3 in MS susceptibility among Finnish MS patients, whereas conclusions on the 19q13.1 subregion are less clear and this region requires further study.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(02)00051-6