Pilomatrix carcinoma with lymph node metastases

Pilomatrix carcinoma is a rare skin tumor with an origin from hair matrix cells. The tumor is locally aggressive with a great tendency for recurrence, but the metastatic potential is limited. A pilomatrix carcinoma in 76‐year‐old female with lymph node metastases is presented. In addition to classic...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2004-04, Vol.31 (4), p.330-335
Main Authors: Bassarova, Assia, Nesland, Jahn M., Sedloev, Theophil, Danielsen, Håvard, Christova, Svetlana
Format: Article
Language:English
Subjects:
Aged
Apoptosis
beta Catenin
Biological and medical sciences
Biomarkers, Tumor - metabolism
Cadherins - metabolism
Cell Division
Cytoskeletal Proteins - metabolism
Dermatology
Diagnosis, Differential
DNA, Neoplasm - analysis
Female
Glycoproteins - metabolism
Hair Diseases - genetics
Hair Diseases - metabolism
Hair Diseases - pathology
Humans
Hyaluronan Receptors - metabolism
Lymph Nodes - pathology
Lymphoma - pathology
Medical sciences
Pilomatrixoma - genetics
Pilomatrixoma - metabolism
Pilomatrixoma - secondary
Ploidies
Skin Neoplasms - genetics
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Trans-Activators - metabolism
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Pilomatrix carcinoma is a rare skin tumor with an origin from hair matrix cells. The tumor is locally aggressive with a great tendency for recurrence, but the metastatic potential is limited. A pilomatrix carcinoma in 76‐year‐old female with lymph node metastases is presented. In addition to classical histopathological criteria and DNA ploidy analysis, a broad panel of antibodies was used for evaluation of the metastatic potential. Both primary tumor and lymph node metastasis revealed extremely high proliferation and apoptotic rates. High constant expressions of CD44v6 and P‐cadherin were also observed. In the metastasis, significant reduction of E‐cadherin and β‐catenin was detected. The best approach for assessment of metastatic potential of pilomatrix carcinoma seems to be the complex evaluation of routine histological criteria like vessel invasion, mitotic index, apoptotic count, and new molecular markers of cell death and adhesion.
ISSN:0303-6987
1600-0560
DOI:10.1111/j.0303-6987.2004.0178.x