Determination of absolute configuration using vibrational circular dichroism spectroscopy: The chiral sulfoxide 1-thiochromanone S-oxide

We reexamined the absolute configuration (AC) of the chiral sulfoxide 1‐thiochromanone S‐oxide (1) using vibrational circular dichroism (VCD) spectroscopy. The VCD spectrum of 1 was analyzed using density functional theory (DFT). DFT predicts two stable conformations of 1, separated by

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Bibliographic Details
Published in:Chirality (New York, N.Y.) N.Y.), 2002, Vol.14 (5), p.400-406
Main Authors: Devlin, F.J., Stephens, P.J., Scafato, P., Superchi, S., Rosini, C.
Format: Article
Language:English
Subjects:
absolute configuration
chiral sulfoxides
vibrational circular dichroism (VCD)
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Summary:We reexamined the absolute configuration (AC) of the chiral sulfoxide 1‐thiochromanone S‐oxide (1) using vibrational circular dichroism (VCD) spectroscopy. The VCD spectrum of 1 was analyzed using density functional theory (DFT). DFT predicts two stable conformations of 1, separated by
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.10103