Characterization of the porcine FABGL gene

The porcine major histocompatibility complex, also called swine lymphocyte antigen (SLA) complex, is of particular interest not only because of its central role in the immune response, but also because of its influence on many traits such as reproduction, fatness and meat quality. The porcine FABGL...

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Bibliographic Details
Published in:Animal genetics 2002-06, Vol.33 (3), p.220-223
Main Authors: Jacobs, K., Mattheeuws, M., Van Poucke, M., Van Zeveren, A., Peelman, L. J.
Format: Article
Language:English
Subjects:
17-Hydroxysteroid Dehydrogenases - genetics
Alcohol Oxidoreductases - genetics
Animals
DNA Primers
FABGL gene
Gene Frequency
Major Histocompatibility Complex - genetics
Organ Specificity
polymorphicism analysis
Promoter Regions, Genetic
SLA
Swine - genetics
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Summary:The porcine major histocompatibility complex, also called swine lymphocyte antigen (SLA) complex, is of particular interest not only because of its central role in the immune response, but also because of its influence on many traits such as reproduction, fatness and meat quality. The porcine FABGL (FabG (beta‐ketoacyl‐[acyl‐carrierprotein] reductase, Escherichia coli) like) gene, coding for a 17β‐hydroxysteroid dehydrogenase (17β‐HSD), is a candidate gene for these traits. The complete gene was sequenced and compared with human and mouse FABGL sequences. The deduced amino acid sequence showed 85 and 83% sequence identity to human and mouse sequences, respectively. Polymorphicic BbvI and DdeI restriction sites were found in the porcine FABGL gene. The promoter was compared with the promoter regions of human and mouse FABGL sequence in order to identify putative regulatory elements. The transcription profile of the porcine gene was determined and showed a widespread tissue distribution.
ISSN:0268-9146
1365-2052
DOI:10.1046/j.1365-2052.2002.00849.x