Keloids – the sebum hypothesis revisited

The aetiology of the keloid scar has not been completely elucidated. Numerous hypotheses have been proposed in the past to explain the unusual characteristics of the keloid scar. While we do know that there is excessive and ongoing collagen-deposition, the exact triggering stimulus is a subject of c...

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Bibliographic Details
Published in:Medical hypotheses 2002-04, Vol.58 (4), p.264-269
Main Authors: Fong, E.P, Bay, B.H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Autoantigens - immunology
Child
Collagen - metabolism
Female
Humans
Hypersensitivity, Delayed - etiology
Hypersensitivity, Delayed - immunology
Keloid - etiology
Keloid - immunology
Keloid - pathology
Male
Microscopy, Electron
Middle Aged
Models, Biological
Postoperative Complications - etiology
Sebaceous Glands - secretion
Sebaceous Glands - ultrastructure
Sebum - immunology
Sebum - secretion
Skin - injuries
T-Lymphocyte Subsets - immunology
Tattooing - adverse effects
Vaccination - adverse effects
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Summary:The aetiology of the keloid scar has not been completely elucidated. Numerous hypotheses have been proposed in the past to explain the unusual characteristics of the keloid scar. While we do know that there is excessive and ongoing collagen-deposition, the exact triggering stimulus is a subject of conjecture. We present some of our photographic records of keloids and electron microscopic findings of keloid edges and reiterate the sebum hypothesis. We also attempt to explain the features of keloids in the light of the present knowledge of immunology and cell biology.
ISSN:0306-9877
1532-2777
DOI:10.1054/mehy.2001.1426