Neuropsychological functioning following bilateral subthalamic nucleus stimulation in Parkinson’s disease

The cognitive effects of subthalamic nucleus (STN) stimulation in Parkinson’s disease (PD) have been examined. However, there are no reported studies that evaluate, by incorporating a disease control group, whether neuropsychological performance in surgical patients changes beyond the variability of...

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Bibliographic Details
Published in:Archives of clinical neuropsychology 2004-03, Vol.19 (2), p.165-181
Main Authors: Morrison, C.E, Borod, J.C, Perrine, K, Beric, A, Brin, M.F, Rezai, A, Kelly, P, Sterio, D, Germano, I, Weisz, D, Olanow, C.W
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Cognition
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Deep brain stimulation (DBS)
Electric Stimulation Therapy - adverse effects
Electrodes, Implanted
Female
Humans
Male
Medical sciences
Middle Aged
Neuropsychological assessment
Neuropsychological Tests
Organic mental disorders. Neuropsychology
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson's disease
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Subthalamic Nucleus - physiopathology
Subthalamic Nucleus - surgery
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Summary:The cognitive effects of subthalamic nucleus (STN) stimulation in Parkinson’s disease (PD) have been examined. However, there are no reported studies that evaluate, by incorporating a disease control group, whether neuropsychological performance in surgical patients changes beyond the variability of the assessment measures. To examine this issue, 17 PD patients were tested before and after bilateral STN stimulator implantation, both on and off stimulation. Eleven matched PD controls were administered the same repeatable neuropsychological test battery twice. Relative to changes seen in the controls, the surgery for electrode placement mildly adversely affected attention and language functions. STN stimulation, per se, had little effect on cognition. The STN DBS procedure as a whole resulted in a mild decline in delayed verbal recall and language functions. There were no surgery, stimulation, or procedure effects on depression scale scores. In contrast to these group findings, one DBS patient demonstrated significant cognitive decline following surgery.
ISSN:0887-6177
1873-5843
DOI:10.1016/S0887-6177(03)00004-0