Intravitreal triamcinolone in the treatment of serous retinal detachment in Vogt-Koyanagi-Harada syndrome

To report the use of intravitreal injection of triamcinolone acetonide during the acute phase of Vogt-Koyanagi-Harada disease. Prospective interventional case series. Three eyes from two patients at the acute phase of Vogt-Koyanagi-Harada disease with serous retinal detachments were treated with a 4...

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Bibliographic Details
Published in:American journal of ophthalmology 2004-03, Vol.137 (3), p.572-574
Main Authors: Andrade, Rafael E., Muccioli, Cristina, Farah, Michel E., Nussenblatt, Robert B., Belfort, Rubens
Format: Article
Language:English
Subjects:
Acute Disease
Biological and medical sciences
Dermatology
Eye
Female
Glucocorticoids - therapeutic use
Humans
Injections
Intraocular Pressure
Medical sciences
Medical treatment
Middle Aged
Ophthalmology
Pharmacology. Drug treatments
Pigmentary diseases of the skin
Prospective Studies
Retina
Retinal Detachment - drug therapy
Retinal Detachment - etiology
Retinal Detachment - pathology
Tomography
Tomography, Optical Coherence
Triamcinolone Acetonide - therapeutic use
Uvea diseases
Uveomeningoencephalitic Syndrome - complications
Uveomeningoencephalitic Syndrome - drug therapy
Uveomeningoencephalitic Syndrome - pathology
Visual Acuity
Vitreous Body
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Summary:To report the use of intravitreal injection of triamcinolone acetonide during the acute phase of Vogt-Koyanagi-Harada disease. Prospective interventional case series. Three eyes from two patients at the acute phase of Vogt-Koyanagi-Harada disease with serous retinal detachments were treated with a 4-mg intravitreal injection of triamcinolone acetonide. The following variables were evaluated: visual acuity, intraocular pressure, and height of the serous retinal detachment using optical coherence tomography. The optical coherence tomography images showed a marked decrease in the retinal detachment in the first week after the injection with subsequent return to normal retinal thickness in all eyes. Intravitreal triamcinolone acetonide provides short-term improvement in visual acuity and serous retinal detachments associated with Vogt-Koyanagi-Harada disease. These findings should be followed by future studies to evaluate long-term effects.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2003.08.035