Antibiotic therapy for severe bacterial infections: correlation between the inhibitory quotient and outcome

In severe bacterial infections, treatment failure can occur even when the infecting organism has displayed in vitro susceptibility to the antibiotics used. Several pharmacokinetic–pharmacodynamic parameters show better correlation with therapeutic outcome than susceptibility results. This study was...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2004-02, Vol.23 (2), p.120-128
Main Authors: Spanu, Teresa, Santangelo, Rosaria, Andreotti, Felicita, Cascio, Giuliana Lo, Velardi, Giuseppe, Fadda, Giovanni
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial therapy
Bacteria - drug effects
Bacterial Infections - drug therapy
Bacterial Infections - physiopathology
Biological and medical sciences
Female
Humans
Inhibitory quotient
Male
Medical sciences
Microbial Sensitivity Tests
Middle Aged
Pharmacology. Drug treatments
Therapeutic outcome
Treatment Outcome
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Summary:In severe bacterial infections, treatment failure can occur even when the infecting organism has displayed in vitro susceptibility to the antibiotics used. Several pharmacokinetic–pharmacodynamic parameters show better correlation with therapeutic outcome than susceptibility results. This study was devised to assess the relation between the inhibitory quotient (IQ), i.e., the ratio of achievable antibiotic concentration at the infection site to the minimum inhibitory concentration for the infecting organism, and both clinical and bacteriological outcomes in 290 severe bacterial infections. Multivariate analysis showed that the IQ was a strong predictor of therapeutic outcome ( P
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2003.06.006