Global high-throughput screens for cellular function

There is a critical need for global methods that allow for high-throughput assessment of cellular function for clinical and basic scientists working in both academia and the pharmaceutical industry. These methods typically couple systematic inactivation strategies with high-throughput cell-based ass...

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Bibliographic Details
Published in:Experimental Hematology 2002-05, Vol.30 (5), p.381-387
Main Authors: Hauptschein, Robert S, Eustace, Brenda K, Jay, Daniel G
Format: Article
Language:English
Subjects:
Animals
Cell Physiological Phenomena
Genetic Testing
Humans
Mass Screening - methods
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Summary:There is a critical need for global methods that allow for high-throughput assessment of cellular function for clinical and basic scientists working in both academia and the pharmaceutical industry. These methods typically couple systematic inactivation strategies with high-throughput cell-based assays that facilitate rapid target validation. We present here a survey of these technologies and their applications. We discuss their promise and limitations in addressing the vast number of candidate molecules of disease relevance that are emerging from genomics and proteomics.
ISSN:0301-472X
1873-2399
DOI:10.1016/S0301-472X(02)00783-X