Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle

We show here, by high resolution sodium dodecyl sulfate gel electrophoresis, that the proportions of myosin heavy chain (MyHC) isoforms of mouse muscles are specifically shifted by hereditary neuromuscular diseases. In wild-type and dystrophic MDX anterior tibial muscle (TA) about 60% of the MyHC is...

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Bibliographic Details
Published in:FEBS letters 2004-03, Vol.561 (1), p.191-194
Main Authors: Agbulut, Onnik, Noirez, Philippe, Butler-Browne, Gillian, Jockusch, Harald
Format: Article
Language:English
Subjects:
ALS, amyotrophic lateral sclerosis
Animals
Electrophoresis, Polyacrylamide Gel
High resolution polyacrylamide gel electrophoresis
Mice
Mice, Mutant Strains
Muscle Denervation
Muscle Fibers, Fast-Twitch - chemistry
Muscle Fibers, Slow-Twitch - chemistry
Muscle, Skeletal - chemistry
Muscle, Skeletal - innervation
Muscle, Skeletal - pathology
Muscular chloride channel ClC-1
Muscular dystrophy ( mdx)
MyHC, myosin heavy chain
Myosin heavy chain isoform
Myosin Heavy Chains - analysis
Myotonia ( adr, mto)
Neuromuscular Diseases - diagnosis
Neuromuscular Diseases - genetics
Neuromuscular Diseases - metabolism
Protein Isoforms - analysis
SMA, spinal muscular atrophy
Spinal muscular atrophy ( wr, mdf)
TA, anterior tibial muscle
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Summary:We show here, by high resolution sodium dodecyl sulfate gel electrophoresis, that the proportions of myosin heavy chain (MyHC) isoforms of mouse muscles are specifically shifted by hereditary neuromuscular diseases. In wild-type and dystrophic MDX anterior tibial muscle (TA) about 60% of the MyHC is IIB, 30% IIX, at most 10% IIA and
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(04)00179-6