Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract

• Published in: Journal of ethnopharmacology 2004-02, Vol.90 (2), p.317-321
• Main Authors: Owoyele, Victor B, Wuraola, Caleb O, Soladoye, Ayodele O, Olaleye, Samuel B
• Format: Article
• Language: English
• Subjects: Analgesic; Analgesics, Non-Narcotic - isolation & purification; Analgesics, Non-Narcotic - pharmacology; Analgesics, Non-Narcotic - therapeutic use; Animals; Anti-inflammatory; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Asteraceae; Biological and medical sciences; Edema - chemically induced; Edema - drug therapy; General pharmacology; Male; Medical sciences; Pain Measurement - drug effects; Pain Measurement - methods; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plant Leaves; Properties; Rats; Rats, Wistar; Tithonia diversifolia (Hemsl) A. Gray
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2003.10.010

A methanol extract of the dried leaves of Tithonia diversifolia was investigated for anti-inflammatory and analgesic activities. The extract (50–200 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with hot plate latency assays maintained at (55 °C) as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of Tithonia diversifolia traditionally for the treatment of painful inflammatory conditions.