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Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract
A methanol extract of the dried leaves of Tithonia diversifolia was investigated for anti-inflammatory and analgesic activities. The extract (50–200 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analges...
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| Published in: | Journal of ethnopharmacology 2004-02, Vol.90 (2), p.317-321 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c445t-57d0a5b3722cbaf6187155d18b73847318fc2c3111f3c81e90e4cfc49586ba793 |
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| cites | cdi_FETCH-LOGICAL-c445t-57d0a5b3722cbaf6187155d18b73847318fc2c3111f3c81e90e4cfc49586ba793 |
| container_end_page | 321 |
| container_issue | 2 |
| container_start_page | 317 |
| container_title | Journal of ethnopharmacology |
| container_volume | 90 |
| creator | Owoyele, Victor B Wuraola, Caleb O Soladoye, Ayodele O Olaleye, Samuel B |
| description | A methanol extract of the dried leaves of
Tithonia diversifolia was investigated for anti-inflammatory and analgesic activities. The extract (50–200
mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with hot plate latency assays maintained at (55
°C) as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of
Tithonia diversifolia traditionally for the treatment of painful inflammatory conditions. |
| doi_str_mv | 10.1016/j.jep.2003.10.010 |
| format | article |
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mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with hot plate latency assays maintained at (55
°C) as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of
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Tithonia diversifolia was investigated for anti-inflammatory and analgesic activities. The extract (50–200
mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with hot plate latency assays maintained at (55
°C) as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of
Tithonia diversifolia traditionally for the treatment of painful inflammatory conditions.</description><subject>Analgesic</subject><subject>Analgesics, Non-Narcotic - isolation & purification</subject><subject>Analgesics, Non-Narcotic - pharmacology</subject><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Animals</subject><subject>Anti-inflammatory</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Asteraceae</subject><subject>Biological and medical sciences</subject><subject>Edema - chemically induced</subject><subject>Edema - drug therapy</subject><subject>General pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pain Measurement - drug effects</subject><subject>Pain Measurement - methods</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Properties</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tithonia diversifolia (Hemsl) A. 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Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Properties</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tithonia diversifolia (Hemsl) A. 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mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with hot plate latency assays maintained at (55
°C) as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of
Tithonia diversifolia traditionally for the treatment of painful inflammatory conditions.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15013196</pmid><doi>10.1016/j.jep.2003.10.010</doi><tpages>5</tpages></addata></record> |
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| issn | 0378-8741 1872-7573 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Analgesic Analgesics, Non-Narcotic - isolation & purification Analgesics, Non-Narcotic - pharmacology Analgesics, Non-Narcotic - therapeutic use Animals Anti-inflammatory Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Asteraceae Biological and medical sciences Edema - chemically induced Edema - drug therapy General pharmacology Male Medical sciences Pain Measurement - drug effects Pain Measurement - methods Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves Properties Rats Rats, Wistar Tithonia diversifolia (Hemsl) A. Gray |
| title | Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract |
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