TestisBank: an internet-based gene sequence database of the testis

The testis is a highly transcriptionally active organ with hundreds of genes expressed during different stages of spermatogenesis. Scientists working on the testis are restricted to using two sources for further information on testicular genes, GenBank and MEDLINE. However, these two databases are n...

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Bibliographic Details
Published in:International journal of andrology 2002-06, Vol.25 (3), p.175-179
Main Authors: Claussen, S., Prokosch, H.-U., Nieschlag, E., Gromoll, J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Databases, Bibliographic
Databases, Genetic
Epididymis
Fundamental and applied biological sciences. Psychology
Humans
Internet
Male
Mammalian male genital system
MEDLINE
Morphology. Physiology
sequence database
spermatogenesis
Testis
testis database
Vertebrates: reproduction
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Description
Summary:The testis is a highly transcriptionally active organ with hundreds of genes expressed during different stages of spermatogenesis. Scientists working on the testis are restricted to using two sources for further information on testicular genes, GenBank and MEDLINE. However, these two databases are not completely linked and give only very little information on the cellular type of expression or whether a gene is cloned in other tissues but is also expressed in the testis. We have generated an organ‐specific database named TestisBank, which is capable of retrieving a more complete set of genes expressed in the different cell types of the testis. Furthermore, it extends to the epididymis which plays an important role in germ cell maturation. TestisBank is automatically updated to match the current status of sequence entries in the genome databases and it provides the user with an interface convenient to handle and provides useful links related to male reproduction. The TestisBank is publicly available at http://medweb.uni‐muenster.de/TestisBank/. The design of the TestisBank may provide a simple model for the development of databases in which molecular and literature data are merged, thereby allowing detailed insight into the contribution of different cells/genes to the complex process of spermatogenesis.
ISSN:0105-6263
1365-2605
DOI:10.1046/j.1365-2605.2002.00347.x