The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury

Both experimental and clinical studies have shown that oxygen-derived free radicals rise in the plasma after thermal injury and participate in the pathogenesis of tissue damage. Hence, various antioxidant molecules have been used in treatment of burn injury both experimentally and clinically. Caffei...

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Bibliographic Details
Published in:Burns 2004-03, Vol.30 (2), p.121-125
Main Authors: Hoşnuter, Mübin, Gürel, Ahmet, Babucçu, Orhan, Armutcu, Ferah, Kargi, Eksal, Işikdemir, Ahmet
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Burns - blood
Burns - drug therapy
Caffeic Acids - pharmacology
CAPE
Lipid peroxidation
Lipid Peroxidation - drug effects
Male
Malondialdehyde - blood
Nitric Oxide - blood
Oxidative Stress - drug effects
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
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Rats
Rats, Wistar
Reactive Oxygen Species - blood
Thermal injury
Xanthine Oxidase - metabolism
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Summary:Both experimental and clinical studies have shown that oxygen-derived free radicals rise in the plasma after thermal injury and participate in the pathogenesis of tissue damage. Hence, various antioxidant molecules have been used in treatment of burn injury both experimentally and clinically. Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have potent antioxidant property. The purpose of the present study was to investigate the effects of CAPE on oxidative stress in plasma of burned rats. Experiment was designed in three groups of rats with 20% full-thickness burn: (a) sham burn ( n=7); (b) burn only ( n=22); (c) burn+treatment with CAPE ( n=22). Plasma levels of malondialdehyde (MDA), nitric oxide (NO) and the activities of xanthine oxidase (XO), and superoxide dismutase (SOD) were used as both bio-indicators of oxidant status and determinant of antioxidant effect of CAPE. They were assessed by biochemical methods at 1st, 3rd, 7th, and 14th post-burn days. In conclusion, CAPE was shown to possess antioxidant activity by saving SOD activity, preventing XO activity and decreasing the levels of MDA, and NO. Our study showed that CAPE may be beneficial in burn injury.
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2003.09.022