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The Matrix Metalloproteinase-21 Gene 572C/T Polymorphism and the Risk of Breast Cancer
Background: Matrix metalloproteinases (MMPs) contribute in multiple ways to all stages of tumor development, and a number of DNA polymorphisms in the MMP genes are associated with an increased risk of cancer. We previously identified the MMP-21 gene 572C/T polymorphism leading to Ala191Val substitut...
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| Published in: | Anticancer research 2004-01, Vol.24 (1), p.199-202 |
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| container_end_page | 202 |
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| container_title | Anticancer research |
| container_volume | 24 |
| creator | Shagisultanova, Elena I Novikova, Inna A Sidorenko, Yuri S Marchenko, George N Strongin, Alex Y Malkhosyan, Sergei R |
| description | Background: Matrix metalloproteinases (MMPs) contribute in multiple ways to all stages of tumor development, and a number
of DNA polymorphisms in the MMP genes are associated with an increased risk of cancer. We previously identified the MMP-21
gene 572C/T polymorphism leading to Ala191Val substitution within the enzyme's catalytic domain. We performed a case-control
study to test association between this polymorphism and the risk of breast cancer. Patients and Methods: 572C/T polymorphism
was analyzed by RFLP method in 396 unrelated Russian females: 76 breast cancer patients and 320 disease-free blood donors.
Results: The frequencies of C/C, T/C and T/T genotypes in patients (69.7%, 25.0% and 5.3%) did not differ significantly form
those in controls (61.9%, 34.7% and 3.4%); the polymorphism was not associated with the increased tumor size and the presence
of metastases. Conclusion: The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression
of breast cancer. |
| format | article |
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of DNA polymorphisms in the MMP genes are associated with an increased risk of cancer. We previously identified the MMP-21
gene 572C/T polymorphism leading to Ala191Val substitution within the enzyme's catalytic domain. We performed a case-control
study to test association between this polymorphism and the risk of breast cancer. Patients and Methods: 572C/T polymorphism
was analyzed by RFLP method in 396 unrelated Russian females: 76 breast cancer patients and 320 disease-free blood donors.
Results: The frequencies of C/C, T/C and T/T genotypes in patients (69.7%, 25.0% and 5.3%) did not differ significantly form
those in controls (61.9%, 34.7% and 3.4%); the polymorphism was not associated with the increased tumor size and the presence
of metastases. Conclusion: The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression
of breast cancer.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 15015597</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms - enzymology ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Case-Control Studies ; Disease Progression ; Female ; Genetic Predisposition to Disease ; Humans ; Matrix Metalloproteinases - genetics ; Matrix Metalloproteinases, Secreted ; Middle Aged ; Polymorphism, Genetic</subject><ispartof>Anticancer research, 2004-01, Vol.24 (1), p.199-202</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15015597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shagisultanova, Elena I</creatorcontrib><creatorcontrib>Novikova, Inna A</creatorcontrib><creatorcontrib>Sidorenko, Yuri S</creatorcontrib><creatorcontrib>Marchenko, George N</creatorcontrib><creatorcontrib>Strongin, Alex Y</creatorcontrib><creatorcontrib>Malkhosyan, Sergei R</creatorcontrib><title>The Matrix Metalloproteinase-21 Gene 572C/T Polymorphism and the Risk of Breast Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Matrix metalloproteinases (MMPs) contribute in multiple ways to all stages of tumor development, and a number
of DNA polymorphisms in the MMP genes are associated with an increased risk of cancer. We previously identified the MMP-21
gene 572C/T polymorphism leading to Ala191Val substitution within the enzyme's catalytic domain. We performed a case-control
study to test association between this polymorphism and the risk of breast cancer. Patients and Methods: 572C/T polymorphism
was analyzed by RFLP method in 396 unrelated Russian females: 76 breast cancer patients and 320 disease-free blood donors.
Results: The frequencies of C/C, T/C and T/T genotypes in patients (69.7%, 25.0% and 5.3%) did not differ significantly form
those in controls (61.9%, 34.7% and 3.4%); the polymorphism was not associated with the increased tumor size and the presence
of metastases. Conclusion: The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression
of breast cancer.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Breast Neoplasms - enzymology</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Case-Control Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Matrix Metalloproteinases - genetics</subject><subject>Matrix Metalloproteinases, Secreted</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqF0E1LAzEQBuAgiq3VvyA5iLfFfGw2m6MWrUKLItVryGYnbnQ_arJF--8NVM-eZgaeGYb3AE2pVDSTgpNDNCVMkEwSIiboJMZ3QopClfwYTaggVAglp-h13QBemTH4b7yC0bTtsAnDCL43ETJG8QJ6wEKy-dUaPw3trhvCpvGxw6av8ZiWn338wIPDNwFMHPHc9BbCKTpypo1w9ltn6OXudj2_z5aPi4f59TJrWCHHrABXuzwvS5CuoMoSyFklXJoqZ5WrpaW2qGUlhHO5VNZRBoantjS5sVXBZ-hyfzc9_bmFOOrORwtta3oYtlFLKhkXNP8Xptg4LUqZ4Pkv3FYd1HoTfGfCTv9FlsDFHjT-rfnyAXTsUmyJc20CyzXVVCn-AxmUdN8</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Shagisultanova, Elena I</creator><creator>Novikova, Inna A</creator><creator>Sidorenko, Yuri S</creator><creator>Marchenko, George N</creator><creator>Strongin, Alex Y</creator><creator>Malkhosyan, Sergei R</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>The Matrix Metalloproteinase-21 Gene 572C/T Polymorphism and the Risk of Breast Cancer</title><author>Shagisultanova, Elena I ; Novikova, Inna A ; Sidorenko, Yuri S ; Marchenko, George N ; Strongin, Alex Y ; Malkhosyan, Sergei R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h267t-6efdf4488e7f619c0e42b5fe7fbfc9fd7c1c6d7b55ff479cf12ea3f478a4acb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Breast Neoplasms - enzymology</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Case-Control Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Matrix Metalloproteinases - genetics</topic><topic>Matrix Metalloproteinases, Secreted</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shagisultanova, Elena I</creatorcontrib><creatorcontrib>Novikova, Inna A</creatorcontrib><creatorcontrib>Sidorenko, Yuri S</creatorcontrib><creatorcontrib>Marchenko, George N</creatorcontrib><creatorcontrib>Strongin, Alex Y</creatorcontrib><creatorcontrib>Malkhosyan, Sergei R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shagisultanova, Elena I</au><au>Novikova, Inna A</au><au>Sidorenko, Yuri S</au><au>Marchenko, George N</au><au>Strongin, Alex Y</au><au>Malkhosyan, Sergei R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Matrix Metalloproteinase-21 Gene 572C/T Polymorphism and the Risk of Breast Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>24</volume><issue>1</issue><spage>199</spage><epage>202</epage><pages>199-202</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Matrix metalloproteinases (MMPs) contribute in multiple ways to all stages of tumor development, and a number
of DNA polymorphisms in the MMP genes are associated with an increased risk of cancer. We previously identified the MMP-21
gene 572C/T polymorphism leading to Ala191Val substitution within the enzyme's catalytic domain. We performed a case-control
study to test association between this polymorphism and the risk of breast cancer. Patients and Methods: 572C/T polymorphism
was analyzed by RFLP method in 396 unrelated Russian females: 76 breast cancer patients and 320 disease-free blood donors.
Results: The frequencies of C/C, T/C and T/T genotypes in patients (69.7%, 25.0% and 5.3%) did not differ significantly form
those in controls (61.9%, 34.7% and 3.4%); the polymorphism was not associated with the increased tumor size and the presence
of metastases. Conclusion: The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression
of breast cancer.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>15015597</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Anticancer research, 2004-01, Vol.24 (1), p.199-202 |
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| language | eng |
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| source | Free E-Journal (出版社公開部分のみ） |
| subjects | Adolescent Adult Aged Aged, 80 and over Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Case-Control Studies Disease Progression Female Genetic Predisposition to Disease Humans Matrix Metalloproteinases - genetics Matrix Metalloproteinases, Secreted Middle Aged Polymorphism, Genetic |
| title | The Matrix Metalloproteinase-21 Gene 572C/T Polymorphism and the Risk of Breast Cancer |
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