Modulation of clinical expression of plaque-induced gingivitis. III. Response of "high responders" and "low responders" to therapy

• Published in: Journal of clinical periodontology 2004-04, Vol.31 (4), p.253-259
• Main Authors: Trombelli, Leonardo, Scapoli, Chiara, Orlandini, Elisa, Tosi, Marina, Bottega, Sabrina, Tatakis, Dimitris N
• Format: Article
• Language: English
• Subjects: Adult; Amines - therapeutic use; Dental Plaque - complications; Dental Plaque - prevention & control; Dental Plaque Index; Dentistry; Drug Combinations; Female; Follow-Up Studies; Gingival Crevicular Fluid - chemistry; Gingival Hemorrhage - classification; Gingivitis - prevention & control; Humans; Male; Matched-Pair Analysis; Mouthwashes - therapeutic use; Oral Hygiene; Patient Satisfaction; Periodontal Index; Statistics, Nonparametric; Tin Fluorides - therapeutic use; Toothpastes - therapeutic use; Treatment Outcome
• ISSN: 0303-6979; 1600-051X
• DOI: 10.1111/j.1600-051x.2004.00479.x

The aim of the present study was to characterize the subject-based clinical behavior of the gingiva in response to a tooth-cleaning regimen in two subpopulations, "high-responder" (HR) and "low-responder" (LR) groups, presenting a different inflammatory response to plaque accumulation. The study population comprised of 96 systemically and periodontally healthy subjects, 46 males and 50 females, non-smokers, enrolled in an experimental gingivitis trial. At completion of the experimental gingivitis period (day 21), all subjects were prescribed the same 21-day treatment regimen of amine/stannous fluoride (AmF/SnF(2))-containing toothpaste and mouthrinse. Plaque index (PlI), gingival index (GI), gingival crevicular fluid volume (GCF), and angulated bleeding score (AngBS) were recorded on three selected teeth. Treatment efficacy was evaluated in the overall population as well as in HR and LR groups, separately. A statistically significant decrease of PlI was observed after treatment (p