Synthesis, crystal structure, antitumor activity and DNA-binding study on the Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline

The complex [Mn(L)(NO(3))(2)(H(2)O)(2)] (1) (L=2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline) was synthesized and characterized by elemental analysis, IR and UV. The crystal and molecular structure of 1 was determined by single-crystal X-ray diffraction; crystal data: light yellow, monoclini...

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Bibliographic Details
Published in:Journal of inorganic biochemistry 2002-06, Vol.90 (3-4), p.79-84
Main Authors: Xu, Zhi Dong, Liu, He, Xiao, Su Long, Yang, Ming, Bu, Xian He
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - metabolism
Antineoplastic Agents - pharmacology
Cattle
Crystallization
Crystallography, X-Ray
DNA - chemistry
DNA - metabolism
Humans
In Vitro Techniques
Manganese - chemistry
Manganese - metabolism
Molecular Structure
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Organometallic Compounds - metabolism
Organometallic Compounds - pharmacology
Spectrophotometry
Tumor Cells, Cultured
Viscosity
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Summary:The complex [Mn(L)(NO(3))(2)(H(2)O)(2)] (1) (L=2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline) was synthesized and characterized by elemental analysis, IR and UV. The crystal and molecular structure of 1 was determined by single-crystal X-ray diffraction; crystal data: light yellow, monoclinic, space group P2(1)/n, Z=4, a=7.432(2) A, b=9.582(3) A, c=23.445(7) A, beta=90.519(5) degrees. The Mn atom in 1 is hexa-coordinated in a distorted octahedral arrangement by two N atoms of the ligand L and four O atoms of two water molecules and two nitrate anions. Biological tests in vitro showed that 1 has significant antitumor activity against HL-60, KB, Hela and BGC-823 cells. The interaction of 1 with calf thymus DNA was investigated by absorption titration, thermal denaturation and viscosity measurements. The results suggest that 1 binds with DNA by intercalating via the ligand L.
ISSN:0162-0134
DOI:10.1016/s0162-0134(02)00416-6