Inverse levels of pigment epithelium-derived factor and vascular endothelial growth factor in the vitreous of eyes with rhegmatogenous retinal detachment and proliferative vitreoretinopathy

• Published in: American journal of ophthalmology 2002-06, Vol.133 (6), p.851-852
• Main Authors: Ogata, Nahoko, Nishikawa, Maki, Nishimura, Tetsuya, Mitsuma, Yumiko, Matsumura, Miyo
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Endothelial Growth Factors - metabolism; Enzyme-Linked Immunosorbent Assay; Eye Proteins - metabolism; Humans; Lymphokines - metabolism; Medical sciences; Nerve Growth Factors; Ophthalmology; Prospective Studies; Proteins - metabolism; Retinal Detachment - metabolism; Retinal Detachment - surgery; Retinal Perforations - metabolism; Retinal Perforations - surgery; Retinopathies; Serpins - metabolism; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the eye and orbit; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vitrectomy; Vitreoretinopathy, Proliferative - metabolism; Vitreoretinopathy, Proliferative - surgery; Vitreous Body - metabolism
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/S0002-9394(02)01406-X

PURPOSE: To determine the vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in eyes with rhegmatogenous retinal detachment and proliferative vitreoretinopathy. DESIGN: Prospective, noncomparative case series. METHODS: Pigment epithelium-derived factor and vascular endothelial growth factor concentrations were measured by enzyme-linked immunosorbent assay in 26 eyes with retinal detachment, 6 with proliferative vitreoretinopathy, and 14 with an idiopathic macular hole. RESULTS: Pigment epithelium-derived factor concentration in proliferative vitreoretinopathy (0.57 ± 0.05 μg/ml) was lower ( P = .0069), and retinal detachment (2.37 ± 0.34 μg/ml) was higher ( P = .16) than that in macular hole (1.71 ± 0.22 μg/ml). Vascular endothelial growth factor concentration (168 ± 139 μg/ml) in proliferative vitreoretinopathy was significantly higher than that in retinal detachment (11 ± 11 μg/ml, P = .0084) and macular hole (not detectable, P = .0095). CONCLUSION: Lower levels of pigment epithelium-derived factor and higher levels of vascular endothelial growth factor may be related to ocular cell proliferation.