Survival signaling in resting B cells

The survival of mature resting B cells in the periphery depends on signaling from the B-cell receptor (BCR) and the B-cell activating factor of the TNF family receptor (BAFF-R). Engagement of both receptors promotes NF-κB activity, which contributes to B-cell survival through different pathways. BCR...

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Bibliographic Details
Published in:Current opinion in immunology 2004-04, Vol.16 (2), p.251-255
Main Authors: Patke, Alina, Mecklenbräuker, Ingrid, Tarakhovsky, Alexander
Format: Article
Language:English
Subjects:
Animals
B-Cell Activation Factor Receptor
B-Lymphocytes - metabolism
Cell Survival
Membrane Proteins - metabolism
Mice
NF-kappa B - metabolism
Receptors, Tumor Necrosis Factor - metabolism
Signal Transduction
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Summary:The survival of mature resting B cells in the periphery depends on signaling from the B-cell receptor (BCR) and the B-cell activating factor of the TNF family receptor (BAFF-R). Engagement of both receptors promotes NF-κB activity, which contributes to B-cell survival through different pathways. BCR signaling leads to activation of the inhibitor of NF-κB kinase (IKK) complex via Carma1, Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-κB2 protein p100, which is dependent on NF-κB-inducing kinase (NIK) and IKKα. Proximal signaling intermediates are potentially common to both pathways. We suggest that BCR and BAFF-R survival signaling are mutually dependent. In addition, we propose that BAFF-R signaling enhances the expression of survival genes through direct chromatin modifications in NF-κB target gene promoters.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2004.01.007