The cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorder

Background: Abnormalities in cAMP signaling and altered expression of downstream targets such as brain-derived neurotrophic factor (BDNF) have been postulated in patients with bipolar disorder (BD). Methods: The PKA activity and levels of 3H–cAMP binding to PKA R regulatory subunits were measured in...

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Bibliographic Details
Published in:Journal of affective disorders 2004-04, Vol.79 (1), p.187-192
Main Authors: Karege, Félicien, Schwald, Michèle, Papadimitriou, Philippe, Lachausse, Christine, Cissé, Mbaye
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
BDNF
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - physiopathology
Bipolar disorders
Brain-Derived Neurotrophic Factor - analysis
Brain-Derived Neurotrophic Factor - biosynthesis
cAMP-dependent PKA
Case-Control Studies
Cyclic AMP-Dependent Protein Kinases - analysis
Cyclic AMP-Dependent Protein Kinases - biosynthesis
Female
Gene Expression Regulation
Humans
Lymphoblast
Lymphocytes
Male
Medical sciences
Middle Aged
Mood disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Signal Transduction
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Summary:Background: Abnormalities in cAMP signaling and altered expression of downstream targets such as brain-derived neurotrophic factor (BDNF) have been postulated in patients with bipolar disorder (BD). Methods: The PKA activity and levels of 3H–cAMP binding to PKA R regulatory subunits were measured in lymphoblasts from 10 BD and 10 control subjects. In addition, the possibility that BDNF expression could be altered in these cells has been explored. Results: Results indicate that PKA activity significantly increased ( t-test; P
ISSN:0165-0327
1573-2517
DOI:10.1016/S0165-0327(02)00463-9