Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists

A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure–activity relationships and identifica...

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Published in:Bioorganic & medicinal chemistry letters 2004-04, Vol.14 (7), p.1761-1764
Main Authors: Sato, Nagaaki, Shibata, Takunobu, Jitsuoka, Makoto, Ohno, Toshiyuki, Takahashi, Toshiyuki, Hirohashi, Tomoko, Kanno, Tetsuya, Iwaasa, Hisashi, Kanatani, Akio, Fukami, Takehiro
Format: Article
Language:English
Subjects:
Aminopyridines - chemistry
Aminopyridines - metabolism
Aminopyridines - pharmacology
Animals
Biological and medical sciences
CHO Cells
Cricetinae
Drug Evaluation, Preclinical - methods
Humans
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
Pharmacology. Drug treatments
Receptors, Neuropeptide Y - antagonists & inhibitors
Receptors, Neuropeptide Y - metabolism
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Summary:A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure–activity relationships and identification of potent 4-alkoxy derivatives are described. A series of substituted 4-alkoxy-2-aminopyridines 2 were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.01.049