Improved high-performance liquid chromatographic method for analysis of l-carnitine in pharmaceutical formulations

A reversed-phase high performance liquid chromatographic method for analysis of l-carnitine is described. The improved method is able to provide a high resolution between l-carnitine and crotonoylbetaine, a major impurity and degradation product, and suitable for quantitative analysis of l-carnitine...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2000-08, Vol.23 (2), p.315-321
Main Authors: He, Gong-Xin, Dahl, Terry
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Calibration
Carnitine - analysis
Chromatography, High Pressure Liquid - methods
General and cellular metabolism. Vitamins
General pharmacology
l-Carnitine
Medical sciences
Pharmaceutical formulations
Pharmaceutical Preparations - chemistry
Pharmacology. Drug treatments
Quantitative analysis
Reproducibility of Results
Reversed-phase high performance liquid chromatography
Spectrophotometry, Ultraviolet
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A reversed-phase high performance liquid chromatographic method for analysis of l-carnitine is described. The improved method is able to provide a high resolution between l-carnitine and crotonoylbetaine, a major impurity and degradation product, and suitable for quantitative analysis of l-carnitine in pharmaceutical formulations, such as solution, tablets, and capsules. The resolution, linearity, accuracy and reproducibility of the method are discussed.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(00)00249-1