Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system of lactic acid polymer releasing pefloxacin

A novel biodegradable system of d-,l-dilactide delivering pefloxacin was implanted in 104 rabbits with experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA), 26 serving as controls. Animals were killed on each third day and viable bacterial counts and levels of pefl...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2000-08, Vol.46 (2), p.311-314
Main Authors: Kanellakopoulou, Kyriaki, Galanakis, Nearchos, Giamarellos-Bourboulis, Evangelos J., Rifiotis, Christos, Papakostas, Konstantinos, Andreopoulos, Andreas, Dounis, Eleftherios, Karagianakos, Panagiotis, Giamarellou, Helen
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Colony Count, Microbial
D,L-Dilactide
Drug Implants
Excipients
Lactic Acid
Male
Medical sciences
methicillin
Methicillin Resistance
osteomyelitis
Osteomyelitis - drug therapy
Osteomyelitis - microbiology
Pefloxacin - administration & dosage
Pefloxacin - pharmacokinetics
Pefloxacin - therapeutic use
perfloxacin
Pharmacology. Drug treatments
Polymers
Rabbits
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus
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Summary:A novel biodegradable system of d-,l-dilactide delivering pefloxacin was implanted in 104 rabbits with experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA), 26 serving as controls. Animals were killed on each third day and viable bacterial counts and levels of pefloxacin in bone tissue were determined. A 99.9% decrease in viable count of bacteria was achieved by day 12 and complete bacterial eradication on day 33. Pefloxacin was released gradually, reaching its peak on day 15 at levels 100 times the MIC of pefloxacin for MRSA. The biodegradable system described may have a future role in the therapeutic approach to osteomyelitis.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/46.2.311