π-Delocalized β-carbolinium cations as potential antimalarials

Several β-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral β-carbolines and a good correlation was observed between π...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-04, Vol.14 (7), p.1689-1692
Main Authors: Takasu, Kiyosei, Shimogama, Tsubasa, Saiin, Chalerm, Kim, Hye-Sook, Wataya, Yusuke, Ihara, Masataka
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials
Antimalarials - chemistry
Antimalarials - pharmacology
Antiparasitic agents
Biological and medical sciences
Carbolines - chemistry
Carbolines - pharmacology
Cations
DLC's
Medical sciences
Pharmacology. Drug treatments
Plasmodium falciparum - drug effects
Plasmodium falciparum - growth & development
Selective toxicity
Total synthesis
β-Carbolines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several β-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral β-carbolines and a good correlation was observed between π-delocalized lipophilic cationic structure and antimalarial efficacy. The synthesis and evaluation for antimalarial potency of β-carbolinium salts are reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.01.055