SCID mice show a similar susceptibility to Angiostrongylus cantonensis as do wild-type mice of the C.B-17 strain

• Published in: Parasitology research (1987) 2000-07, Vol.86 (7), p.542-550
• Main Authors: YOSHIMURA, K, SUGAYA, H, AOKI, M, ISHIDA, K
• Format: Article
• Language: English
• Subjects: Angiostrongylus cantonensis - immunology; Angiostrongylus cantonensis - pathogenicity; Animals; Antibodies, Helminth - blood; Antibodies, Helminth - immunology; Antigens, Helminth - immunology; Biological and medical sciences; Biomphalaria; Bone Marrow; Disease Susceptibility; Eosinophilia; Experimental helminthic diseases. Models; Gene Expression; Helminthic diseases; Infectious diseases; Interleukin-3 - biosynthesis; Interleukin-5 - biosynthesis; Leukocytes - immunology; Male; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mice, SCID - immunology; Morbidity; Parasitic diseases; Rats; Receptors, Interleukin - genetics; Receptors, Interleukin-3 - genetics; Receptors, Interleukin-5; Strongylida Infections - blood; Strongylida Infections - cerebrospinal fluid; Strongylida Infections - immunology
• ISSN: 0932-0113; 1432-1955
• DOI: 10.1007/s004360000200

C.B-17-SCID/SCID (SCID) mice infected with Angiostrongylus cantonensis yielded a high percentage of worm recovery and did not show any body weight loss until day 24 postinfection. Unexpectedly, C.B-17-+/+(+/+) mice also produced a similar worm burden containing well-developed worms. This is probably attributable to the observation that +/+ mice failed to induce eosinophilia in cerebrospinal fluid (CSF) despite their production of antigen-specific IgA and IgGI; +/+ mice have defective bone-marrow eosinopoiesis, which in turn results in reduced blood and CSF eosinophilia. Interleukin 5 (IL-5) production in +/+ mice is similar to that in BALB/c and C57BL/6 mice. However, bone-marrow eosinopoiesis in response to IL-5 is markedly suppressed in +/+ mice. This is probably associated with impaired expression of common beta-chain mRNA in bone-marrow cells of +/+ mice, which leads to the failure of bone-marrow eosinopoiesis. Hence, +/+ mice may serve as a useful model for the elucidation of eosinophil production in the mouse and for determination of the relationship between parasite infection and the eosinophil.