CD43 has a functional NLS, interacts with β-catenin, and affects gene expression

CD43 is a transmembrane molecule with a highly O-glycosylated extracellular domain of mucin type. It is a normal constituent of leukocytes and found in colon adenoma, but not in normal colon epithelia. Here it is shown that the cytoplasmic tail of CD43 contains a functional bipartite nuclear localiz...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2004-03, Vol.316 (1), p.12-17
Main Authors: Andersson, Christian X, Fernandez-Rodriguez, Julia, Laos, Sirle, Sikut, Rein, Sikut, Anu, Baeckström, Dan, Hansson, Gunnar C
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antigens, CD
beta Catenin
CD43
Cell Line
Cytoskeletal Proteins - metabolism
Leukosialin
Molecular Sequence Data
Mucin
NLS
Nuclear Localization Signals
Nucleus
Sialoglycoproteins - chemistry
Sialoglycoproteins - metabolism
Sialoglycoproteins - physiology
Trans-Activators - metabolism
Transcriptional Activation
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Summary:CD43 is a transmembrane molecule with a highly O-glycosylated extracellular domain of mucin type. It is a normal constituent of leukocytes and found in colon adenoma, but not in normal colon epithelia. Here it is shown that the cytoplasmic tail of CD43 contains a functional bipartite nuclear localization signal directing it to the nucleus. The intracellular domain of CD43 interacts with β-catenin and causes an upregulation of the β-catenin target genes c-MYC and CyclinD1. The present results suggest that CD43 can be involved in nuclear signaling and via β-catenin interaction be involved in cell proliferation.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2004.02.011