Altered Placental Oxidative Stress Status in Gestational Diabetes Mellitus

• Published in: Placenta (Eastbourne) 2004, Vol.25 (1), p.78-84
• Main Authors: Coughlan, M.T., Vervaart, P.P., Permezel, M., Georgiou, H.M., Rice, G.E.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Biomarkers - blood; Cell Survival; Cesarean Section; Culture Techniques; Diabetes, Gestational - metabolism; Dinoprost - analogs & derivatives; Dinoprost - metabolism; Diseases of mother, fetus and pregnancy; Female; Glucose Tolerance Test; Glutathione Peroxidase - metabolism; Gynecology. Andrology. Obstetrics; Humans; Medical sciences; Oxidative Stress; Placenta - metabolism; Pregnancy; Pregnancy. Fetus. Placenta; Superoxide Dismutase - metabolism
• ISSN: 0143-4004; 1532-3102
• DOI: 10.1016/S0143-4004(03)00183-8

Oxidative stress has been clearly linked to type 2 diabetes mellitus, however, limited data are available on the involvement of oxidative stress in gestational diabetes mellitus (GDM), a disease of similar pathophysiology. The aim of this study was to investigate the status of placental oxidative stress in healthy pregnant women and women with GDM. The hypothesis to be tested was that tissue markers of oxidative stress are significantly increased in GDM compared to normal placental tissues. Markers of oxidative stress measured were the release of 8-isoprostane (8-epi-prostaglandin F 2α) from human term placental explants ( n=11), the activity of the antioxidant enzymes superoxide dismutase and glutathione peroxidase ( n=10), and protein carbonyl content ( n=12). Placental release of 8-isoprostane was 2-fold greater from women with GDM ( P